2j4e: Difference between revisions

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[[Image:2j4e.gif|left|200px]]<br /><applet load="2j4e" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2j4e.gif|left|200px]]
caption="2j4e, resolution 2.80&Aring;" />
 
'''THE ITP COMPLEX OF HUMAN INOSINE TRIPHOSPHATASE'''<br />
{{Structure
|PDB= 2j4e |SIZE=350|CAPTION= <scene name='initialview01'>2j4e</scene>, resolution 2.80&Aring;
|SITE= <scene name='pdbsite=AC1:Mg+Binding+Site+For+Chain+H'>AC1</scene>
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ITT:INOSINE+5'-TRIPHOSPHATE'>ITT</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene> and <scene name='pdbligand=IMP:INOSINIC ACID'>IMP</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Nucleoside-triphosphate_diphosphatase Nucleoside-triphosphate diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.19 3.6.1.19]
|GENE=
}}
 
'''THE ITP COMPLEX OF HUMAN INOSINE TRIPHOSPHATASE'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2J4E is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=ITT:'>ITT</scene>, <scene name='pdbligand=POP:'>POP</scene> and <scene name='pdbligand=IMP:'>IMP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Nucleoside-triphosphate_diphosphatase Nucleoside-triphosphate diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.19 3.6.1.19] Known structural/functional Site: <scene name='pdbsite=AC1:Mg+Binding+Site+For+Chain+H'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J4E OCA].  
2J4E is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J4E OCA].  


==Reference==
==Reference==
Crystal structure of human inosine triphosphatase. Substrate binding and implication of the inosine triphosphatase deficiency mutation P32T., Stenmark P, Kursula P, Flodin S, Graslund S, Landry R, Nordlund P, Schuler H, J Biol Chem. 2007 Feb 2;282(5):3182-7. Epub 2006 Nov 29. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17138556 17138556]
Crystal structure of human inosine triphosphatase. Substrate binding and implication of the inosine triphosphatase deficiency mutation P32T., Stenmark P, Kursula P, Flodin S, Graslund S, Landry R, Nordlund P, Schuler H, J Biol Chem. 2007 Feb 2;282(5):3182-7. Epub 2006 Nov 29. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17138556 17138556]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Nucleoside-triphosphate diphosphatase]]
[[Category: Nucleoside-triphosphate diphosphatase]]
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[[Category: nucleotide metabolism]]
[[Category: nucleotide metabolism]]


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