2j6m: Difference between revisions

Line 1:

[[Image:2j6m.jpg|left|200px]]~~<br /><applet load~~="2j6m~~" size~~="350~~" color~~=~~"white" frame~~=~~"true" align="right" spinBox="true"~~

[[Image:2j6m.jpg|left|200px]]

~~caption="~~2j6m, resolution 3.10Å" />

'''CRYSTAL STRUCTURE OF EGFR KINASE DOMAIN IN COMPLEX WITH AEE788'''~~<br />~~

{{Structure

|PDB= 2j6m |SIZE=350|CAPTION= <scene name='initialview01'>2j6m</scene>, resolution 3.10Å

|SITE= <scene name='pdbsite=AC1:Aee+Binding+Site+For+Residue+A+2021'>AC1</scene>

|LIGAND= <scene name='pdbligand=AEE:6-{4-[(4-ETHYLPIPERAZIN-1-YL)METHYL]PHENYL}-N-[(1R)-1-PHENYLETHYL]-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE'>AEE</scene>

|ACTIVITY=

|GENE=

}}

'''CRYSTAL STRUCTURE OF EGFR KINASE DOMAIN IN COMPLEX WITH AEE788'''

==Overview==

Line 10:

Line 19:

==About this Structure==

2J6M is a [~~http://en.wikipedia.org/wiki/Single_protein~~ Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=AEE:'>AEE</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Aee+Binding+Site+For+Residue+A+2021'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J6M OCA].

2J6M is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J6M OCA].

==Reference==

Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity., Yun CH, Boggon TJ, Li Y, Woo MS, Greulich H, Meyerson M, Eck MJ, Cancer Cell. 2007 Mar;11(3):217-27. PMID:[http://~~ispc~~.~~weizmann~~.ac.~~il/~~/~~pmbin~~/~~getpm?pmid=~~17349580 17349580]

Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity., Yun CH, Boggon TJ, Li Y, Woo MS, Greulich H, Meyerson M, Eck MJ, Cancer Cell. 2007 Mar;11(3):217-27. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17349580 17349580]

[[Category: Homo sapiens]]

[[Category: Single protein]]

Line 45:

Line 54:

[[Category: wild-type]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu ~~Feb 21~~ 17:59:48 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:38:03 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:2j6m.jpg|left|200px]]<br /><applet load="2j6m" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:2j6m.jpg|left|200px]]
-caption="2j6m, resolution 3.10&Aring;" />
-'''CRYSTAL STRUCTURE OF EGFR KINASE DOMAIN IN COMPLEX WITH AEE788'''<br />
+ {{Structure
+|PDB= 2j6m |SIZE=350|CAPTION= <scene name='initialview01'>2j6m</scene>, resolution 3.10&Aring;
+|SITE= <scene name='pdbsite=AC1:Aee+Binding+Site+For+Residue+A+2021'>AC1</scene>
+|LIGAND= <scene name='pdbligand=AEE:6-{4-[(4-ETHYLPIPERAZIN-1-YL)METHYL]PHENYL}-N-[(1R)-1-PHENYLETHYL]-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE'>AEE</scene>
+|ACTIVITY=
+|GENE=
+}}
+'''CRYSTAL STRUCTURE OF EGFR KINASE DOMAIN IN COMPLEX WITH AEE788'''
 ==Overview==
@@ Line 10: / Line 19: @@
 ==About this Structure==
-J6M is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=AEE:'>AEE</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Aee+Binding+Site+For+Residue+A+2021'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J6M OCA].
+J6M is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J6M OCA].
 ==Reference==
-Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity., Yun CH, Boggon TJ, Li Y, Woo MS, Greulich H, Meyerson M, Eck MJ, Cancer Cell. 2007 Mar;11(3):217-27. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17349580 17349580]
+Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity., Yun CH, Boggon TJ, Li Y, Woo MS, Greulich H, Meyerson M, Eck MJ, Cancer Cell. 2007 Mar;11(3):217-27. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17349580 17349580]
 [[Category: Homo sapiens]]
 [[Category: Single protein]]
@@ Line 45: / Line 54: @@
 [[Category: wild-type]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:59:48 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:38:03 2008''