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{{STRUCTURE_4g8h|  PDB=4g8h  |  SCENE=  }}
==Crystal structure of C-lobe of bovine lactoferrin complexed with licofelone at 1.88 A resolution==
===Crystal structure of C-lobe of bovine lactoferrin complexed with licofelone at 1.88 A resolution===
<StructureSection load='4g8h' size='340' side='right' caption='[[4g8h]], [[Resolution|resolution]] 1.88&Aring;' scene=''>
 
== Structural highlights ==
==Function==
<table><tr><td colspan='2'>[[4g8h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G8H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G8H FirstGlance]. <br>
[[http://www.uniprot.org/uniprot/TRFL_BOVIN TRFL_BOVIN]] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref>   Lactotransferrin has antimicrobial activity. The most effective inhibitory activity was seen against E.coli and P.aeruginosa.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref>   Lactoferricin B is an antimicrobial peptide. Inhibits the growth of Gram-negative and Gram-positive bacteria.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref>   The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=LCF:[6-(4-CHLOROPHENYL)-2,2-DIMETHYL-7-PHENYL-2,3-DIHYDRO-1H-PYRROLIZIN-5-YL]ACETIC+ACID'>LCF</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
 
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3rgy|3rgy]]</td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g8h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g8h RCSB], [http://www.ebi.ac.uk/pdbsum/4g8h PDBsum]</span></td></tr>
[[4g8h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G8H OCA].  
</table>


==See Also==
==See Also==
*[[Lactoferrin|Lactoferrin]]
*[[Lactoferrin|Lactoferrin]]
 
__TOC__
==Reference==
</StructureSection>
<references group="xtra"/><references/>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Gautam, L.]]
[[Category: Gautam, L]]
[[Category: Kaur, P.]]
[[Category: Kaur, P]]
[[Category: Sharma, S.]]
[[Category: Sharma, S]]
[[Category: Shukla, P K.]]
[[Category: Shukla, P K]]
[[Category: Singh, T P.]]
[[Category: Singh, T P]]
[[Category: Sinha, M.]]
[[Category: Sinha, M]]
[[Category: C-lobe]]
[[Category: C-lobe]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Metal binding protein]]
[[Category: Metal binding protein]]

Revision as of 11:31, 21 December 2014

Crystal structure of C-lobe of bovine lactoferrin complexed with licofelone at 1.88 A resolution

4g8h, resolution 1.88Å

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