4fvl: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Human collagenase 3 (MMP-13) full form with peptides from pro-domain===

~~The~~ entry ~~4fvl is ON HOLD~~ ~~until Aug 17 2014~~

==Disease==

[[http://www.uniprot.org/uniprot/MMP13_HUMAN MMP13_HUMAN]] Defects in MMP13 are the cause of spondyloepimetaphyseal dysplasia Missouri type (SEMD-MO) [MIM:[http://omim.org/entry/602111 602111]]. A bone disease characterized by moderate to severe metaphyseal changes, mild epiphyseal involvement, rhizomelic shortening of the lower limbs with bowing of the femora and/or tibiae, coxa vara, genu varum and pear-shaped vertebrae in childhood. Epimetaphyseal changes improve with age.<ref>PMID:16167086</ref> Defects in MMP13 are the cause of metaphyseal anadysplasia type 1 (MANDP1) [MIM:[http://omim.org/entry/602111 602111]]. Metaphyseal anadysplasia consists of an abnormal bone development characterized by severe skeletal changes that, in contrast with the progressive course of most other skeletal dysplasias, resolve spontaneously with age. Clinical characteristics are evident from the first months of life and include slight shortness of stature and a mild varus deformity of the legs. Patients attain a normal stature in adolescence and show improvement or complete resolution of varus deformity of the legs and rhizomelic micromelia.<ref>PMID:19615667</ref>

~~Authors~~: ~~Stura, E~~.A.~~, Vera, L~~.~~, Visse, R~~.~~, Nagase, H., Dive, V~~.

==Function==

[[http://www.uniprot.org/uniprot/MMP13_HUMAN MMP13_HUMAN]] Degrades collagen type I. Does not act on gelatin or casein. Could have a role in tumoral process.

~~Description~~: ~~Human collagenase 3 (MMP~~-~~13) full form~~ with ~~peptides from pro~~-~~domain~~

==About this Structure==

[[4fvl]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FVL OCA].

==Reference==

[[Category: Homo sapiens]]

[[Category: Dive, V.]]

[[Category: Nagase, H.]]

[[Category: Stura, E A.]]

[[Category: Vera, L.]]

[[Category: Visse, R.]]

[[Category: Cleavage with mmp3]]

[[Category: Collagen]]

[[Category: Collagen cleavage]]

[[Category: Collagenase]]

[[Category: Hydrolase]]

[[Category: Metzincin]]

[[Category: Pro-peptide]]

[[Category: Protein-peptide complex]]

[[Category: Zinc metalloprotease]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4fvl|  PDB=4fvl  |  SCENE=  }}
+===Human collagenase 3 (MMP-13) full form with peptides from pro-domain===
+{{ABSTRACT_PUBMED_23913860}}
-The entry 4fvl is ON HOLD  until Aug 17 2014
+==Disease==
+[[http://www.uniprot.org/uniprot/MMP13_HUMAN MMP13_HUMAN]] Defects in MMP13 are the cause of spondyloepimetaphyseal dysplasia Missouri type (SEMD-MO) [MIM:[http://omim.org/entry/602111 602111]]. A bone disease characterized by moderate to severe metaphyseal changes, mild epiphyseal involvement, rhizomelic shortening of the lower limbs with bowing of the femora and/or tibiae, coxa vara, genu varum and pear-shaped vertebrae in childhood. Epimetaphyseal changes improve with age.<ref>PMID:16167086</ref>   Defects in MMP13 are the cause of metaphyseal anadysplasia type 1 (MANDP1) [MIM:[http://omim.org/entry/602111 602111]]. Metaphyseal anadysplasia consists of an abnormal bone development characterized by severe skeletal changes that, in contrast with the progressive course of most other skeletal dysplasias, resolve spontaneously with age. Clinical characteristics are evident from the first months of life and include slight shortness of stature and a mild varus deformity of the legs. Patients attain a normal stature in adolescence and show improvement or complete resolution of varus deformity of the legs and rhizomelic micromelia.<ref>PMID:19615667</ref>
-Authors: Stura, E.A., Vera, L., Visse, R., Nagase, H., Dive, V.
+==Function==
+[[http://www.uniprot.org/uniprot/MMP13_HUMAN MMP13_HUMAN]] Degrades collagen type I. Does not act on gelatin or casein. Could have a role in tumoral process.
-Description: Human collagenase 3 (MMP-13) full form with peptides from pro-domain
+==About this Structure==
+[[4fvl]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FVL OCA].
+==Reference==
+<ref group="xtra">PMID:023913860</ref><references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Dive, V.]]
+[[Category: Nagase, H.]]
+[[Category: Stura, E A.]]
+[[Category: Vera, L.]]
+[[Category: Visse, R.]]
+[[Category: Cleavage with mmp3]]
+[[Category: Collagen]]
+[[Category: Collagen cleavage]]
+[[Category: Collagenase]]
+[[Category: Hydrolase]]
+[[Category: Metzincin]]
+[[Category: Pro-peptide]]
+[[Category: Protein-peptide complex]]
+[[Category: Zinc metalloprotease]]