4kq8: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Structure of Recombinant Human Cytochrome P450 Aromatase===

~~The~~ entry ~~4kq8~~ is ~~ON HOLD~~ ~~until Paper Publication~~

==Disease==

[[http://www.uniprot.org/uniprot/CP19A_HUMAN CP19A_HUMAN]] Defects in CYP19A1 are a cause of aromatase excess syndrome (AEXS) [MIM:[http://omim.org/entry/139300 139300]]; also known as familial gynecomastia. AEXS is characterized by an estrogen excess due to an increased aromatase activity. Defects in CYP19A1 are the cause of aromatase deficiency (AROD) [MIM:[http://omim.org/entry/613546 613546]]. AROD is a rare disease in which fetal androgens are not converted into estrogens due to placental aromatase deficiency. Thus, pregnant women exhibit a hirsutism, which spontaneously resolves after post-partum. At birth, female babies present with pseudohermaphroditism due to virilization of extern genital organs. In adult females, manifestations include delay of puberty, breast hypoplasia and primary amenorrhoea with multicystic ovaries.<ref>PMID:8265607</ref> <ref>PMID:8530621</ref> <ref>PMID:9211678</ref>

~~Authors~~: ~~Ghosh, D~~.~~, Di Nardo, G~~.~~, Griswold, J~~.

==Function==

[[http://www.uniprot.org/uniprot/CP19A_HUMAN CP19A_HUMAN]] Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

~~Description~~: ~~Structure of Recombinant Human~~ Cytochrome ~~P450 Aromatase~~

==About this Structure==

[[4kq8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KQ8 OCA].

==Reference==

[[Category: Homo sapiens]]

[[Category: Unspecific monooxygenase]]

[[Category: Ghosh, D.]]

[[Category: Griswold, J.]]

[[Category: Nardo, G Di.]]

[[Category: Androgen]]

[[Category: Aromatase]]

[[Category: Cytochrome p450]]

[[Category: Cytochrome p450 reductase]]

[[Category: Estrogen]]

[[Category: Estrogen synthetase]]

[[Category: Oxidoreductase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4kq8|  PDB=4kq8  |  SCENE=  }}
+===Structure of Recombinant Human Cytochrome P450 Aromatase===
+{{ABSTRACT_PUBMED_23899247}}
-The entry 4kq8 is ON HOLD  until Paper Publication
+==Disease==
+[[http://www.uniprot.org/uniprot/CP19A_HUMAN CP19A_HUMAN]] Defects in CYP19A1 are a cause of aromatase excess syndrome (AEXS) [MIM:[http://omim.org/entry/139300 139300]]; also known as familial gynecomastia. AEXS is characterized by an estrogen excess due to an increased aromatase activity.  Defects in CYP19A1 are the cause of aromatase deficiency (AROD) [MIM:[http://omim.org/entry/613546 613546]]. AROD is a rare disease in which fetal androgens are not converted into estrogens due to placental aromatase deficiency. Thus, pregnant women exhibit a hirsutism, which spontaneously resolves after post-partum. At birth, female babies present with pseudohermaphroditism due to virilization of extern genital organs. In adult females, manifestations include delay of puberty, breast hypoplasia and primary amenorrhoea with multicystic ovaries.<ref>PMID:8265607</ref> <ref>PMID:8530621</ref> <ref>PMID:9211678</ref>
-Authors: Ghosh, D., Di Nardo, G., Griswold, J.
+==Function==
+[[http://www.uniprot.org/uniprot/CP19A_HUMAN CP19A_HUMAN]] Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
-Description: Structure of Recombinant Human Cytochrome P450 Aromatase
+==About this Structure==
+[[4kq8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KQ8 OCA].
+==Reference==
+<ref group="xtra">PMID:023899247</ref><references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Unspecific monooxygenase]]
+[[Category: Ghosh, D.]]
+[[Category: Griswold, J.]]
+[[Category: Nardo, G Di.]]
+[[Category: Androgen]]
+[[Category: Aromatase]]
+[[Category: Cytochrome p450]]
+[[Category: Cytochrome p450 reductase]]
+[[Category: Estrogen]]
+[[Category: Estrogen synthetase]]
+[[Category: Oxidoreductase]]