4l0r: Difference between revisions
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{{STRUCTURE_4l0r| PDB=4l0r | SCENE= }} | |||
===Crystal structure of FGF2-interacting protein from Homo sapiens. Northeast Structural Genomics Consortium Target HR9027A.=== | |||
The entry | ==Disease== | ||
[[http://www.uniprot.org/uniprot/CEP57_HUMAN CEP57_HUMAN]] Mosaic variegated aneuploidy syndrome. The disease is caused by mutations affecting the gene represented in this entry. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CEP57_HUMAN CEP57_HUMAN]] Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring-like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2, but that of FGF1.<ref>PMID:22321063</ref> | |||
==About this Structure== | |||
[[4l0r]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L0R OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Acton, T B.]] | |||
[[Category: Ciccosanti, C.]] | |||
[[Category: Everett, J K.]] | |||
[[Category: Hunt, J F.]] | |||
[[Category: Lew, S.]] | |||
[[Category: Montelione, G T.]] | |||
[[Category: NESG, Northeast Structural Genomics Consortium.]] | |||
[[Category: Sahdev, S.]] | |||
[[Category: Seetharaman, J.]] | |||
[[Category: Su, M.]] | |||
[[Category: Tong, L.]] | |||
[[Category: Xiao, R.]] | |||
[[Category: Cell cycle]] | |||
[[Category: Centrosomal protein]] | |||
[[Category: Cep57]] | |||
[[Category: Nesg]] | |||
[[Category: Northeast structural genomics consortium]] | |||
[[Category: Psi-biology]] | |||
[[Category: Structural genomic]] | |||
Revision as of 11:00, 4 September 2013
Crystal structure of FGF2-interacting protein from Homo sapiens. Northeast Structural Genomics Consortium Target HR9027A.
Disease
[CEP57_HUMAN] Mosaic variegated aneuploidy syndrome. The disease is caused by mutations affecting the gene represented in this entry.
Function
[CEP57_HUMAN] Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring-like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2, but that of FGF1.[1]
About this Structure
4l0r is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- ↑ Zhen Y, Sorensen V, Skjerpen CS, Haugsten EM, Jin Y, Walchli S, Olsnes S, Wiedlocha A. Nuclear import of exogenous FGF1 requires the ER-protein LRRC59 and the importins Kpnalpha1 and Kpnbeta1. Traffic. 2012 May;13(5):650-64. doi: 10.1111/j.1600-0854.2012.01341.x. Epub 2012 , Mar 4. PMID:22321063 doi:10.1111/j.1600-0854.2012.01341.x
