4lj7: Difference between revisions
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{{STRUCTURE_4lj7| PDB=4lj7 | SCENE= }} | |||
===ClpB NBD2 K601Q from T. thermophilus in complex with MANT-dADP=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CLPB_THET8 CLPB_THET8]] Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK.<ref>PMID:10377389</ref> | |||
==About this Structure== | |||
[[4lj7]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LJ7 OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Barends, T R.M.]] | |||
[[Category: Reinstein, J.]] | |||
[[Category: Schlichting, I.]] | |||
[[Category: Werbeck, N D.]] | |||
[[Category: Zeymer, C.]] | |||
[[Category: Aaa+ protein]] | |||
[[Category: Chaperone]] | |||
[[Category: Disaggregase]] | |||
[[Category: Molecular chaperone]] | |||
[[Category: Nucleotide binding domain]] | |||
Revision as of 05:19, 13 February 2014
ClpB NBD2 K601Q from T. thermophilus in complex with MANT-dADP
Function
[CLPB_THET8] Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK.[1]
About this Structure
4lj7 is a 3 chain structure. Full crystallographic information is available from OCA.
