4lmq: Difference between revisions

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'''Unreleased structure'''
{{STRUCTURE_4lmq|  PDB=4lmq  |  SCENE=  }}
===Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12===
{{ABSTRACT_PUBMED_23812669}}


The entry 4lmq is ON HOLD until Paper Publication
==Function==
[[http://www.uniprot.org/uniprot/SDF1_HUMAN SDF1_HUMAN]] Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to another C-X-C chemokine receptor CXCR7, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and CXCR7, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of CXCR7 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation.<ref>PMID:8752281</ref> <ref>PMID:11069075</ref> <ref>PMID:11859124</ref> <ref>PMID:16107333</ref> <ref>PMID:18802065</ref> <ref>PMID:19255243</ref>  


Authors: Zhong, Z., Wang, J., Li, B., Xiang, H., Ultsch, M., Coons, M., Wong, T, Chiang, N.Y., Clark, S., Clark, R., Quintana, L., Gribling, P., Suto, E., Barck, K., Corpuz, R., Yao, J., Takkar, R., Lee, W.P., Damico-Beyer, L.A., Carano, R.D., Adams, C., Kelley, R.F., Wang, W., Ferrara, N.
==About this Structure==
[[4lmq]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LMQ OCA].  


Description: Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12
==Reference==
<ref group="xtra">PMID:023812669</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Adams, C.]]
[[Category: Barck, K.]]
[[Category: Carano, R D.]]
[[Category: Chiang, N Y.]]
[[Category: Clark, R.]]
[[Category: Clark, S.]]
[[Category: Coons, M.]]
[[Category: Corpuz, R.]]
[[Category: Damico-Beyer, L A.]]
[[Category: Ferrara, N.]]
[[Category: Gribling, P.]]
[[Category: Kelley, R F.]]
[[Category: Lee, W P.]]
[[Category: Li, B.]]
[[Category: Quintana, L.]]
[[Category: Suto, E.]]
[[Category: Takkar, R.]]
[[Category: Ultsch, M.]]
[[Category: Wang, J.]]
[[Category: Wang, W.]]
[[Category: Wong, T]]
[[Category: Xiang, H.]]
[[Category: Yao, J.]]
[[Category: Zhong, Z.]]
[[Category: Cell adhesion-immune system complex]]
[[Category: Immunoglobulin]]
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