4lwd: Difference between revisions
From Proteopedia
Jump to navigationJump to search
m Protected "4lwd" [edit=sysop:move=sysop] |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_4lwd| PDB=4lwd | SCENE= }} | |||
===Human CARMA1 CARD domain=== | |||
{{ABSTRACT_PUBMED_24074955}} | |||
The entry | ==Disease== | ||
[[http://www.uniprot.org/uniprot/CAR11_HUMAN CAR11_HUMAN]] Persistent polyclonal B-cell lymphocytosis. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CAR11_HUMAN CAR11_HUMAN]] Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10. | |||
==About this Structure== | |||
[[4lwd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LWD OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024074955</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Wu, H.]] | |||
[[Category: Zheng, C.]] | |||
[[Category: Bcl10]] | |||
[[Category: Death domain]] | |||
[[Category: Signaling protein]] | |||
Revision as of 08:01, 16 October 2013
Human CARMA1 CARD domain
Template:ABSTRACT PUBMED 24074955
Disease
[CAR11_HUMAN] Persistent polyclonal B-cell lymphocytosis. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
Function
[CAR11_HUMAN] Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.
About this Structure
4lwd is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Qiao Q, Yang C, Zheng C, Fontan L, David L, Yu X, Bracken C, Rosen M, Melnick A, Egelman EH, Wu H. Structural Architecture of the CARMA1/Bcl10/MALT1 Signalosome: Nucleation-Induced Filamentous Assembly. Mol Cell. 2013 Sep 26;51(6):766-79. doi: 10.1016/j.molcel.2013.08.032. PMID:24074955 doi:https://dx.doi.org/10.1016/j.molcel.2013.08.032
