2jbp: Difference between revisions

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[[Image:2jbp.jpg|left|200px]]<br /><applet load="2jbp" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2jbp.jpg|left|200px]]
caption="2jbp, resolution 3.31&Aring;" />
 
'''PROTEIN KINASE MK2 IN COMPLEX WITH AN INHIBITOR (CRYSTAL FORM-2, CO-CRYSTALLIZATION)'''<br />
{{Structure
|PDB= 2jbp |SIZE=350|CAPTION= <scene name='initialview01'>2jbp</scene>, resolution 3.31&Aring;
|SITE= <scene name='pdbsite=AC1:P4o+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:P4o+Binding+Site+For+Chain+B'>AC2</scene>, <scene name='pdbsite=AC3:P4o+Binding+Site+For+Chain+C'>AC3</scene>, <scene name='pdbsite=AC4:P4o+Binding+Site+For+Chain+D'>AC4</scene>, <scene name='pdbsite=AC5:P4o+Binding+Site+For+Chain+E'>AC5</scene>, <scene name='pdbsite=AC6:P4o+Binding+Site+For+Chain+F'>AC6</scene>, <scene name='pdbsite=AC7:P4o+Binding+Site+For+Chain+G'>AC7</scene>, <scene name='pdbsite=AC8:P4o+Binding+Site+For+Chain+H'>AC8</scene>, <scene name='pdbsite=AC9:P4o+Binding+Site+For+Chain+I'>AC9</scene>, <scene name='pdbsite=BC1:P4o+Binding+Site+For+Chain+K'>BC1</scene> and <scene name='pdbsite=BC2:P4o+Binding+Site+For+Chain+L'>BC2</scene>
|LIGAND= <scene name='pdbligand=P4O:2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE'>P4O</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1]
|GENE=
}}
 
'''PROTEIN KINASE MK2 IN COMPLEX WITH AN INHIBITOR (CRYSTAL FORM-2, CO-CRYSTALLIZATION)'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2JBP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=P4O:'>P4O</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] Known structural/functional Sites: <scene name='pdbsite=AC1:P4o+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:P4o+Binding+Site+For+Chain+B'>AC2</scene>, <scene name='pdbsite=AC3:P4o+Binding+Site+For+Chain+C'>AC3</scene>, <scene name='pdbsite=AC4:P4o+Binding+Site+For+Chain+D'>AC4</scene>, <scene name='pdbsite=AC5:P4o+Binding+Site+For+Chain+E'>AC5</scene>, <scene name='pdbsite=AC6:P4o+Binding+Site+For+Chain+F'>AC6</scene>, <scene name='pdbsite=AC7:P4o+Binding+Site+For+Chain+G'>AC7</scene>, <scene name='pdbsite=AC8:P4o+Binding+Site+For+Chain+H'>AC8</scene>, <scene name='pdbsite=AC9:P4o+Binding+Site+For+Chain+I'>AC9</scene>, <scene name='pdbsite=BC1:P4o+Binding+Site+For+Chain+K'>BC1</scene> and <scene name='pdbsite=BC2:P4o+Binding+Site+For+Chain+L'>BC2</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JBP OCA].  
2JBP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JBP OCA].  


==Reference==
==Reference==
Structural basis for a high affinity inhibitor bound to protein kinase MK2., Hillig RC, Eberspaecher U, Monteclaro F, Huber M, Nguyen D, Mengel A, Muller-Tiemann B, Egner U, J Mol Biol. 2007 Jun 8;369(3):735-45. Epub 2007 Mar 12. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17449059 17449059]
Structural basis for a high affinity inhibitor bound to protein kinase MK2., Hillig RC, Eberspaecher U, Monteclaro F, Huber M, Nguyen D, Mengel A, Muller-Tiemann B, Egner U, J Mol Biol. 2007 Jun 8;369(3):735-45. Epub 2007 Mar 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17449059 17449059]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: transferase]]
[[Category: transferase]]


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