2je5: Difference between revisions

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[[Image:2je5.jpg|left|200px]]<br /><applet load="2je5" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2je5.jpg|left|200px]]
caption="2je5, resolution 2.60&Aring;" />
 
'''STRUCTURAL AND MECHANISTIC BASIS OF PENICILLIN BINDING PROTEIN INHIBITION BY LACTIVICINS'''<br />
{{Structure
|PDB= 2je5 |SIZE=350|CAPTION= <scene name='initialview01'>2je5</scene>, resolution 2.60&Aring;
|SITE= <scene name='pdbsite=AC1:L4c+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:L4c+Binding+Site+For+Chain+B'>AC2</scene>, <scene name='pdbsite=AC3:So4+Binding+Site+For+Chain+B'>AC3</scene>, <scene name='pdbsite=AC4:So4+Binding+Site+For+Chain+A'>AC4</scene>, <scene name='pdbsite=AC5:Cl+Binding+Site+For+Chain+A'>AC5</scene>, <scene name='pdbsite=AC6:Cl+Binding+Site+For+Chain+A'>AC6</scene>, <scene name='pdbsite=AC7:Cl+Binding+Site+For+Chain+B'>AC7</scene> and <scene name='pdbsite=AC8:Cl+Binding+Site+For+Chain+B'>AC8</scene>
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene> and <scene name='pdbligand=L4C:(2E)-2-{[(2S)-2-(ACETYLAMINO)-2-CARBOXYETHOXY]IMINO}PENTANEDIOIC ACID'>L4C</scene>
|ACTIVITY=
|GENE=
}}
 
'''STRUCTURAL AND MECHANISTIC BASIS OF PENICILLIN BINDING PROTEIN INHIBITION BY LACTIVICINS'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2JE5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae] with <scene name='pdbligand=SO4:'>SO4</scene>, <scene name='pdbligand=CL:'>CL</scene> and <scene name='pdbligand=L4C:'>L4C</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Sites: <scene name='pdbsite=AC1:L4c+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:L4c+Binding+Site+For+Chain+B'>AC2</scene>, <scene name='pdbsite=AC3:So4+Binding+Site+For+Chain+B'>AC3</scene>, <scene name='pdbsite=AC4:So4+Binding+Site+For+Chain+A'>AC4</scene>, <scene name='pdbsite=AC5:Cl+Binding+Site+For+Chain+A'>AC5</scene>, <scene name='pdbsite=AC6:Cl+Binding+Site+For+Chain+A'>AC6</scene>, <scene name='pdbsite=AC7:Cl+Binding+Site+For+Chain+B'>AC7</scene> and <scene name='pdbsite=AC8:Cl+Binding+Site+For+Chain+B'>AC8</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JE5 OCA].  
2JE5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JE5 OCA].  


==Reference==
==Reference==
Structural and mechanistic basis of penicillin-binding protein inhibition by lactivicins., Macheboeuf P, Fischer DS, Brown T Jr, Zervosen A, Luxen A, Joris B, Dessen A, Schofield CJ, Nat Chem Biol. 2007 Sep;3(9):565-9. Epub 2007 Aug 5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17676039 17676039]
Structural and mechanistic basis of penicillin-binding protein inhibition by lactivicins., Macheboeuf P, Fischer DS, Brown T Jr, Zervosen A, Luxen A, Joris B, Dessen A, Schofield CJ, Nat Chem Biol. 2007 Sep;3(9):565-9. Epub 2007 Aug 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17676039 17676039]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Streptococcus pneumoniae]]
[[Category: Streptococcus pneumoniae]]
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[[Category: cell wall]]
[[Category: cell wall]]
[[Category: drug-binding protein]]
[[Category: drug-binding protein]]
[[Category: gamma lactam antibiotics]]
[[Category: gamma lactam antibiotic]]
[[Category: peptidoglycan]]
[[Category: peptidoglycan]]
[[Category: peptidoglycan synthesis multifunctional enzyme]]
[[Category: peptidoglycan synthesis multifunctional enzyme]]


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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:40:47 2008''
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