4ga8: Difference between revisions

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~~{{STRUCTURE_4ga8| PDB=4ga8 | SCENE= }}~~

==Human AKR1B10 mutant V301L complexed with NADP+ and sorbinil==

===Human AKR1B10 mutant V301L complexed with NADP+ and sorbinil===

== Structural highlights ==

==~~Function~~==

<table><tr><td colspan='2'>[[4ga8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GA8 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GA8 FirstGlance].

[[~~http://www.uniprot.org/uniprot/AK1BA_HUMAN AK1BA_HUMAN~~]] ~~Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes~~, ~~and is less active on hexoses (in vitro)~~. ~~May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.<ref~~>~~PMID:18087047</ref>~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SBI:SORBINIL'>SBI</scene></td></tr>

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[1zua|1zua]]</td></tr>

==~~About this Structure~~==

<tr id='gene'><td class="sblockLbl">[[Gene|Gene:]]</td><td class="sblockDat">AKR1B10, AKR1B11 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>

[[4ga8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GA8 OCA].

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ga8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ga8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ga8 RCSB], [http://www.ebi.ac.uk/pdbsum/4ga8 PDBsum]</td></tr>

</table>

==~~Reference~~==

__TOC__

<~~references group~~="~~xtra~~"/><~~references~~/>

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Cousido-Siah, A.]]

[[Category: Cousido-Siah, A]]

[[Category: Figueras, F X.Ruiz.]]

[[Category: Figueras, F X.Ruiz]]

[[Category: Mitschler, A.]]

[[Category: Mitschler, A]]

[[Category: Podjarny, A.]]

[[Category: Podjarny, A]]

[[Category: Aldo-keto reductase]]

[[Category: Oxidoreductase]]

[[Category: Tim barrel]]

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@@ Line 1: / Line 1: @@
-{{STRUCTURE_4ga8|  PDB=4ga8  |  SCENE=  }}
+==Human AKR1B10 mutant V301L complexed with NADP+ and sorbinil==
-===Human AKR1B10 mutant V301L complexed with NADP+ and sorbinil===
+<StructureSection load='4ga8' size='340' side='right' caption='[[4ga8]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
+== Structural highlights ==
-==Function==
+<table><tr><td colspan='2'>[[4ga8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GA8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GA8 FirstGlance]. <br>
-[[http://www.uniprot.org/uniprot/AK1BA_HUMAN AK1BA_HUMAN]] Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.<ref>PMID:18087047</ref>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SBI:SORBINIL'>SBI</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1zua|1zua]]</td></tr>
-==About this Structure==
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AKR1B10, AKR1B11 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-[[4ga8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GA8 OCA].
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ga8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ga8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ga8 RCSB], [http://www.ebi.ac.uk/pdbsum/4ga8 PDBsum]</span></td></tr>
+</table>
-==Reference==
+__TOC__
-<references group="xtra"/><references/>
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Cousido-Siah, A.]]
+[[Category: Cousido-Siah, A]]
-[[Category: Figueras, F X.Ruiz.]]
+[[Category: Figueras, F X.Ruiz]]
-[[Category: Mitschler, A.]]
+[[Category: Mitschler, A]]
-[[Category: Podjarny, A.]]
+[[Category: Podjarny, A]]
 [[Category: Aldo-keto reductase]]
 [[Category: Oxidoreductase]]
 [[Category: Tim barrel]]