4kax: Difference between revisions
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{{STRUCTURE_4kax| PDB=4kax | SCENE= }} | {{STRUCTURE_4kax| PDB=4kax | SCENE= }} | ||
===Crystal structure of the Grp1 PH domain in complex with Arf6-GTP=== | ===Crystal structure of the Grp1 PH domain in complex with Arf6-GTP=== | ||
{{ABSTRACT_PUBMED_23940353}} | |||
==Function== | ==Function== | ||
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==Reference== | ==Reference== | ||
<references group="xtra"/><references/> | <ref group="xtra">PMID:023940353</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Berg, B van den.]] | [[Category: Berg, B van den.]] | ||
Revision as of 05:03, 28 August 2013
Crystal structure of the Grp1 PH domain in complex with Arf6-GTP
Template:ABSTRACT PUBMED 23940353
Function
[ARF6_HUMAN] GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton remodeling. May modulate vesicle budding and uncoating within the Golgi apparatus. Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in the regulation of dendritic spine development (By similarity). Contributes to the regulation of dendritic branching and filopodia extension.[1] [2] [3] [CYH3_HUMAN] Promotes guanine-nucleotide exchange on ARF1. Promotes the activation of ARF through replacement of GDP with GTP.
About this Structure
4kax is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Malaby AW, van den Berg B, Lambright DG. Structural basis for membrane recruitment and allosteric activation of cytohesin family Arf GTPase exchange factors. Proc Natl Acad Sci U S A. 2013 Aug 12. PMID:23940353 doi:10.1073/pnas.1301883110
- ↑ D'Souza-Schorey C, Stahl PD. Myristoylation is required for the intracellular localization and endocytic function of ARF6. Exp Cell Res. 1995 Nov;221(1):153-9. PMID:7589240 doi:https://dx.doi.org/10.1006/excr.1995.1362
- ↑ Gauthier-Campbell C, Bredt DS, Murphy TH, El-Husseini Ael-D. Regulation of dendritic branching and filopodia formation in hippocampal neurons by specific acylated protein motifs. Mol Biol Cell. 2004 May;15(5):2205-17. Epub 2004 Feb 20. PMID:14978216 doi:10.1091/mbc.E03-07-0493
- ↑ Pasqualato S, Menetrey J, Franco M, Cherfils J. The structural GDP/GTP cycle of human Arf6. EMBO Rep. 2001 Mar;2(3):234-8. PMID:11266366 doi:10.1093/embo-reports/kve043
