Sandbox 127: Difference between revisions
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position of the cephalosporin backbone are able to interact with additional amino acid | position of the cephalosporin backbone are able to interact with additional amino acid | ||
residues in PBP2a; specifically | residues in PBP2a; specifically | ||
<scene name='37/372724/Medicine_interaction/2'>Tyr446 and Met641</scene>.The | <scene name='37/372724/Medicine_interaction/2'>Tyr446 and Met641</scene>. The | ||
<scene name='37/372724/Medicine_interaction/1'> medicine</scene> shown as colors of the atom types ([[CPK]]) is able to more efficiently react with <scene name='37/372724/R2_interaction/9'>Ser403</scene> and therefore inhibit the activity of PBP2a as a result of ceftobiprole <scene name='37/372724/R2_interaction/8'>tighter binding</scene> to PBP2a. Unlike penicillin, this results in inhibition of PBP2a. | <scene name='37/372724/Medicine_interaction/1'> medicine</scene> shown as colors of the atom types ([[CPK]]) is able to more efficiently react with <scene name='37/372724/R2_interaction/9'>Ser403</scene> and therefore inhibit the activity of PBP2a as a result of ceftobiprole <scene name='37/372724/R2_interaction/8'>tighter binding</scene> to PBP2a. Unlike penicillin, this results in inhibition of PBP2a. | ||
