4ln0: Difference between revisions

Line 1:

~~'''Unreleased~~ structure~~'''~~

===Crystal structure of the VGLL4-TEAD4 complex===

The ~~entry 4ln0~~ is ~~ON HOLD until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/TEAD4_MOUSE TEAD4_MOUSE]] Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif (By similarity). Might play a role in the embryonic development of skeletal muscle. [[http://www.uniprot.org/uniprot/VGLL4_MOUSE VGLL4_MOUSE]] May act as a specific coactivator for the mammalian TEFs (By similarity).

~~Authors~~: ~~Wang, H.Z., Shi, Z~~.B.~~, Zhou, Z~~.C.

==About this Structure==

[[4ln0]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LN0 OCA].

~~Description~~: ~~The VT complex~~

==Reference==

[[Category: Shi, Z.]]

[[Category: Wang, H.]]

[[Category: Zhou, Z.]]

[[Category: Development]]

[[Category: Tea/atts domain family]]

[[Category: Transcription]]

[[Category: Transcription cofactor]]

[[Category: Transcription factor]]

[[Category: Vestigial/tondu family]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4ln0|  PDB=4ln0  |  SCENE=  }}
+===Crystal structure of the VGLL4-TEAD4 complex===
+{{ABSTRACT_PUBMED_24525233}}
-The entry 4ln0 is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/TEAD4_MOUSE TEAD4_MOUSE]] Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif (By similarity). Might play a role in the embryonic development of skeletal muscle. [[http://www.uniprot.org/uniprot/VGLL4_MOUSE VGLL4_MOUSE]] May act as a specific coactivator for the mammalian TEFs (By similarity).
-Authors: Wang, H.Z., Shi, Z.B., Zhou, Z.C.
+==About this Structure==
+[[4ln0]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LN0 OCA].
-Description: The VT complex
+==Reference==
+<ref group="xtra">PMID:024525233</ref><references group="xtra"/><references/>
+[[Category: Shi, Z.]]
+[[Category: Wang, H.]]
+[[Category: Zhou, Z.]]
+[[Category: Development]]
+[[Category: Tea/atts domain family]]
+[[Category: Transcription]]
+[[Category: Transcription cofactor]]
+[[Category: Transcription factor]]
+[[Category: Vestigial/tondu family]]