4lv8: Difference between revisions
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{{STRUCTURE_4lv8| PDB=4lv8 | SCENE= }} | |||
===Murine IRGa6 bound to Toxoplasma ROP5C, a pseudokinase GDI=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/IIGP1_MOUSE IIGP1_MOUSE]] GTPase with low activity. Has higher affinity for GDP than for GTP. Plays a role in resistance to intracellular pathogens. Required for disruption of the parasitophorous vacuole formed following T.gondii infection and subsequent killing of the parasite. Mediates resistance to C.trachomatis infection by targeting bacterial inclusions to autophagosomes for subsequent lysosomal destruction.<ref>PMID:11907101</ref> <ref>PMID:16304607</ref> <ref>PMID:19242543</ref> <ref>PMID:12732635</ref> | |||
==About this Structure== | |||
[[4lv8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Toxoplasma_gondii_type_i Toxoplasma gondii type i]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LV8 OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Mus musculus]] | |||
[[Category: Toxoplasma gondii type i]] | |||
[[Category: Boothroyd, J C.]] | |||
[[Category: Reese, M L.]] | |||
[[Category: Guanine dissociation inhibitor]] | |||
[[Category: Immune related gtpase]] | |||
[[Category: Parasite effector]] | |||
[[Category: Transferase-hydrolase complex]] | |||
