2jt6: Difference between revisions

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New page: left|200px<br /><applet load="2jt6" size="350" color="white" frame="true" align="right" spinBox="true" caption="2jt6" /> '''Solution structure of matrix metalloproteina...
 
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[[Image:2jt6.jpg|left|200px]]<br /><applet load="2jt6" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2jt6.jpg|left|200px]]
caption="2jt6" />
 
'''Solution structure of matrix metalloproteinase 3 (MMP-3) in the presence of 3-4'-cyanobyphenyl-4-yloxy)-n-hdydroxypropionamide (MMP-3 inhibitor VII)'''<br />
{{Structure
|PDB= 2jt6 |SIZE=350|CAPTION= <scene name='initialview01'>2jt6</scene>
|SITE= <scene name='pdbsite=AC1:Zn+Binding+Site+For+Residue+A+256'>AC1</scene>, <scene name='pdbsite=AC2:Zn+Binding+Site+For+Residue+A+257'>AC2</scene>, <scene name='pdbsite=AC3:Ca+Binding+Site+For+Residue+A+258'>AC3</scene>, <scene name='pdbsite=AC4:Ca+Binding+Site+For+Residue+A+259'>AC4</scene> and <scene name='pdbsite=AC5:Jt6+Binding+Site+For+Residue+A+1'>AC5</scene>
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=JT6:'>JT6</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Stromelysin_1 Stromelysin 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.17 3.4.24.17]
|GENE= MMP3, STMY1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Solution structure of matrix metalloproteinase 3 (MMP-3) in the presence of 3-4'-cyanobyphenyl-4-yloxy)-n-hdydroxypropionamide (MMP-3 inhibitor VII)'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2JT6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=JT6:'>JT6</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Stromelysin_1 Stromelysin 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.17 3.4.24.17] Known structural/functional Sites: <scene name='pdbsite=AC1:Zn+Binding+Site+For+Residue+A+256'>AC1</scene>, <scene name='pdbsite=AC2:Zn+Binding+Site+For+Residue+A+257'>AC2</scene>, <scene name='pdbsite=AC3:Ca+Binding+Site+For+Residue+A+258'>AC3</scene>, <scene name='pdbsite=AC4:Ca+Binding+Site+For+Residue+A+259'>AC4</scene> and <scene name='pdbsite=AC5:Jt6+Binding+Site+For+Residue+A+1'>AC5</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JT6 OCA].  
2JT6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JT6 OCA].  


==Reference==
==Reference==
Matrix metalloproteinase-inhibitor interaction: the solution structure of the catalytic domain of human matrix metalloproteinase-3 with different inhibitors., Alcaraz LA, Banci L, Bertini I, Cantini F, Donaire A, Gonnelli L, J Biol Inorg Chem. 2007 Nov;12(8):1197-206. Epub 2007 Aug 21. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17710450 17710450]
Matrix metalloproteinase-inhibitor interaction: the solution structure of the catalytic domain of human matrix metalloproteinase-3 with different inhibitors., Alcaraz LA, Banci L, Bertini I, Cantini F, Donaire A, Gonnelli L, J Biol Inorg Chem. 2007 Nov;12(8):1197-206. Epub 2007 Aug 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17710450 17710450]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: zymogen]]
[[Category: zymogen]]


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