3wg6: Difference between revisions
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== | ==Crystal structure of conjugated polyketone reductase C1 from Candida parapsilosis complexed with NADPH== | ||
[[3wg6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/ | <StructureSection load='3wg6' size='340' side='right' caption='[[3wg6]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3wg6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_22019 Atcc 22019]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WG6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WG6 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cpr-c1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5480 ATCC 22019])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wg6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wg6 OCA], [http://pdbe.org/3wg6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3wg6 RCSB], [http://www.ebi.ac.uk/pdbsum/3wg6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3wg6 ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Conjugated polyketone reductase (CPR-C1) from Candida parapsilosis IFO 0708 is a member of the aldo-keto reductase (AKR) superfamily and reduces ketopantoyl lactone to D-pantoyl lactone in a NADPH-dependent and stereospecific manner. We determined the crystal structure of CPR-C1.NADPH complex at 2.20 A resolution. CPR-C1 adopted a triose-phosphate isomerase (TIM) barrel fold at the core of the structure in which Thr25 and Lys26 of the GXGTX motif bind uniquely to the adenosine 2'-phosphate group of NADPH. This finding provides a novel structural basis for NADPH binding of the AKR superfamily. (c) Proteins 2013;. (c) 2013 Wiley Periodicals, Inc. | |||
Crystal structure of conjugated polyketone reductase (CPR-C1) from Candida parapsilosis IFO 0708 complexed with NADPH.,Qin HM, Yamamura A, Miyakawa T, Kataoka M, Maruoka S, Ohtsuka J, Nagata K, Shimizu S, Tanokura M Proteins. 2013 Jul 15. doi: 10.1002/prot.24363. PMID:23852710<ref>PMID:23852710</ref> | |||
<ref | |||
[[Category: | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
[[Category: Kataoka, M | </div> | ||
[[Category: Maruoka, S | <div class="pdbe-citations 3wg6" style="background-color:#fffaf0;"></div> | ||
[[Category: Miyakawa, T | == References == | ||
[[Category: Nagata, K | <references/> | ||
[[Category: Ohtsuka, J | __TOC__ | ||
[[Category: Qin, H M | </StructureSection> | ||
[[Category: Shimizu, S | [[Category: Atcc 22019]] | ||
[[Category: Tanokura, M | [[Category: Kataoka, M]] | ||
[[Category: Yamamura, A | [[Category: Maruoka, S]] | ||
[[Category: Miyakawa, T]] | |||
[[Category: Nagata, K]] | |||
[[Category: Ohtsuka, J]] | |||
[[Category: Qin, H M]] | |||
[[Category: Shimizu, S]] | |||
[[Category: Tanokura, M]] | |||
[[Category: Yamamura, A]] | |||
[[Category: Akr superfamily]] | [[Category: Akr superfamily]] | ||
[[Category: D-pantoyl lactone]] | [[Category: D-pantoyl lactone]] | ||
[[Category: Oxidoreductase]] | [[Category: Oxidoreductase]] | ||
[[Category: Tim barrel]] | [[Category: Tim barrel]] | ||
