Adaptin

<StructureSection load='2vgl' size='350' side='right' caption='Structure of Adaptin core: AP-α (grey), AP-β (light green), AP-μ (green), AP-σ (olive green) complex with inositole hexakisphosphate (PDB entry 2vgl)' scene=> Adaptin (AP) are proteins which mediate the formation of vescicles by clathrin-coated pits. The AP complex is a hetertetramer composed of 2 large AP: AP-α or AP-γ and AP-β, a medium-size AP: AP-μ and small AP: AP-σ. AP complexes connect proteins and lipids to clathrin budding sites. There are different AP complexes in mammals.

AP-α

1b9x, 1qts – mAP appendage domain – mouse
1qtp – mAP appendage domain (mutant)
1ky6, 1kyd – mAP appendage domain + epsin peptide
1ky7 – mAP appendage domain + amphiphysin peptide
1kyf, 1kyu – mAP appendage domain + eps15 peptide
1w80, 2vj0 – mAP appendage domain + synaptojanin peptide
3hs8 – mAP appendage domain + intersectin peptide

AP-β

1e42 - hAP appendage domain - human
2g30 – hAP appendage domain + ARH peptide
2iv9 – hAP appendage domain + eps15 peptide
2iv8 – hAP appendage domain + B-arrestin peptide
3h1z – hAP appendage domain + PTDINSPKI-γ peptide
3hs9 – hAP appendage domain + intersectin peptide

AP-γ

1iu1, 2e9g, 4bcx – hAP ear domain
2ymt – hAP ear domain + peptide
3zhf – hAP ear domain + large envelope protein peptide
1gyu, 2a7b – mAP appendage domain
1gyv, 1gyw, 3zy7 – mAP appendage domain (mutant)

AP-δ

4afi – hAP/vesicle-associated membrane protein 7

AP-μ

1bw8, 1i31 – rAP + EGFR peptide
1bxx – rAP + TGN38 peptide
1hes – rAP + selectin peptide
2bp5 – rAP + purinoceptor peptide
2pr9 – rAP + GABA receptor peptide
3h85 – rAP appendage domain + PTDINSPKIgamma peptide
4emz, 4en2 – mAP sorting motif recognition domain + nef + MHC-I

AP-α + AP-β + AP-μ + AP-σ

2vgl – rAPα + APβ + APμ + APσ
2jkr, 2jkt – mAPα + APβ + APμ + APσ + CD4 peptide
2xa7 – rAPα + APβ + APμ + APσ + cargo peptide

AP-γ + AP-β + AP-μ + AP-σ

1w63 – mAPγ + APβ + APμ + APσ
4hmy – mAPγ + APβ + APμ + APσ + ADP-ribosylation factor

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky