2mb9: Difference between revisions
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{{STRUCTURE_2mb9| PDB=2mb9 | SCENE= }} | |||
===Human Bcl10 CARD=== | |||
{{ABSTRACT_PUBMED_24074955}} | |||
The entry | ==Disease== | ||
[[http://www.uniprot.org/uniprot/BCL10_HUMAN BCL10_HUMAN]] A chromosomal aberration involving BCL10 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(1;14)(p22;q32). Although the BCL10/IgH translocation leaves the coding region of BCL10 intact, frequent BCL10 mutations could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions. Defects in BCL10 are involved in various types of cancer. The gene represented in this entry may be involved in disease pathogenesis. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/BCL10_HUMAN BCL10_HUMAN]] Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1.<ref>PMID:18264101</ref> | |||
==About this Structure== | |||
[[2mb9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MB9 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024074955</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Bracken, C.]] | |||
[[Category: Wu, H.]] | |||
[[Category: Zheng, C.]] | |||
[[Category: Apoptosis]] | |||
[[Category: Death domain]] | |||
[[Category: Signaling protein]] | |||
