4c2i: Difference between revisions

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'''Unreleased structure'''
{{STRUCTURE_4c2i|  PDB=4c2i  |  SCENE=  }}
===Cryo-EM structure of Dengue virus serotype 1 complexed with Fab fragments of human antibody 1F4===
{{ABSTRACT_PUBMED_24421336}}


The entry 4c2i is ON HOLD  until Paper Publication
==Function==
[[http://www.uniprot.org/uniprot/Q7TGE4_9FLAV Q7TGE4_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS027287_004_099774] [[http://www.uniprot.org/uniprot/G3F5K5_9FLAV G3F5K5_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774]


Authors: Fibriansah, G., Tan, J.L., de Alwis, R., Smith, S.A., Ng, T.-S., Kostyuchenko, V.A., Ibarra, K.D., Harris, E., de Silva, A., Crowe Junior, J.E., Lok, S.-M.
==About this Structure==
[[4c2i]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_serotype_1 Dengue virus serotype 1] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C2I OCA].  


Description: Cryo-EM structure of Dengue virus serotype 1 complexed with Fab fragments of human antibody 1F4
==Reference==
<ref group="xtra">PMID:024421336</ref><references group="xtra"/><references/>
[[Category: Dengue virus serotype 1]]
[[Category: Homo sapiens]]
[[Category: Alwis, R de.]]
[[Category: Fibriansah, G.]]
[[Category: Harris, E.]]
[[Category: Ibarra, K D.]]
[[Category: Junior, J E.Crowe.]]
[[Category: Kostyuchenko, V A.]]
[[Category: Lok, S M.]]
[[Category: Ng, T S.]]
[[Category: Silva, A de.]]
[[Category: Smith, S A.]]
[[Category: Tan, J L.]]
[[Category: E protein]]
[[Category: Neutralization]]
[[Category: Virus]]
Retrieved from "https://proteopedia.org/4c2i"