4c2v: Difference between revisions
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{{STRUCTURE_4c2v| PDB=4c2v | SCENE= }} | |||
===Aurora B kinase in complex with the specific inhibitor Barasertib=== | |||
The | ==Function== | ||
[[http://www.uniprot.org/uniprot/AUKBA_XENLA AUKBA_XENLA]] Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Phosphorylates 'Ser-10' of histone H3 during mitosis.<ref>PMID:12221116</ref> <ref>PMID:11350965</ref> <ref>PMID:17199039</ref> [[http://www.uniprot.org/uniprot/INCEA_XENLA INCEA_XENLA]] Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Probably acts through association with aurkb or aurkc. Seems to bind directly to microtubules.<ref>PMID:12221116</ref> <ref>PMID:17199039</ref> | |||
==About this Structure== | |||
[[4c2v]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C2V OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Non-specific serine/threonine protein kinase]] | |||
[[Category: Sessa, F.]] | |||
[[Category: Villa, F.]] | |||
[[Category: Azd1152]] | |||
[[Category: Transferase-cell cycle complex]] | |||
