4ldc: Difference between revisions
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{{STRUCTURE_4ldc| PDB=4ldc | SCENE= }} | |||
===Crystal Structure of DOC2B C2B domain=== | |||
{{ABSTRACT_PUBMED_23994332}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/DOC2B_RAT DOC2B_RAT]] Calcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes.<ref>PMID:18596155</ref> <ref>PMID:20150444</ref> | |||
==About this Structure== | |||
[[4ldc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LDC OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023994332</ref><references group="xtra"/><references/> | |||
[[Category: Rattus norvegicus]] | |||
[[Category: Almagor, L.]] | |||
[[Category: Giladi, M.]] | |||
[[Category: Hirsch, J A.]] | |||
[[Category: C2]] | |||
[[Category: Calcium binding domain]] | |||
[[Category: Metal binding protein]] | |||
