4lk9: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Crystal Structure of MOZ double PHD finger histone H3 tail complex===

~~The entry 4lk9~~ is ~~ON HOLD until Paper Publication~~

==Disease==

[[http://www.uniprot.org/uniprot/KAT6A_HUMAN KAT6A_HUMAN]] Note=Chromosomal aberrations involving KAT6A may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with CREBBP; translocation t(8;22)(p11;q13) with EP300. KAT6A-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation. Note=A chromosomal aberration involving KAT6A is a cause of therapy-related myelodysplastic syndrome. Translocation t(2;8)(p23;p11.2) with ASXL2 generates a KAT6A-ASXL2 fusion protein.

~~Authors~~: ~~Dreveny, I~~.~~, Deeves, S~~.E.~~, Yue, B~~.~~, Heery, D.M~~.

==Function==

[[http://www.uniprot.org/uniprot/KAT6A_HUMAN KAT6A_HUMAN]] Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2.<ref>PMID:11742995</ref> <ref>PMID:11965546</ref> <ref>PMID:12771199</ref> <ref>PMID:16387653</ref> <ref>PMID:17925393</ref>

~~Description~~: ~~Crystal Structure of MOZ double PHD~~ finger ~~histone~~ H3 tail ~~complex~~

==About this Structure==

[[4lk9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LK9 OCA].

==Reference==

[[Category: Histone acetyltransferase]]

[[Category: Homo sapiens]]

[[Category: Deeves, S E.]]

[[Category: Dreveny, I.]]

[[Category: Heery, D M.]]

[[Category: Yue, B.]]

[[Category: Double phd finger]]

[[Category: Dpf]]

[[Category: H3 tail]]

[[Category: Histone acetyltransferase]]

[[Category: Histone h3]]

[[Category: Plant homeodomain finger]]

[[Category: Transferase]]

[[Category: Zinc finger]]

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-'''Unreleased structure'''
+{{STRUCTURE_4lk9|  PDB=4lk9  |  SCENE=  }}
+===Crystal Structure of MOZ double PHD finger histone H3 tail complex===
-The entry 4lk9 is ON HOLD  until Paper Publication
+==Disease==
+[[http://www.uniprot.org/uniprot/KAT6A_HUMAN KAT6A_HUMAN]] Note=Chromosomal aberrations involving KAT6A may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with CREBBP; translocation t(8;22)(p11;q13) with EP300. KAT6A-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.  Note=A chromosomal aberration involving KAT6A is a cause of therapy-related myelodysplastic syndrome. Translocation t(2;8)(p23;p11.2) with ASXL2 generates a KAT6A-ASXL2 fusion protein.
-Authors: Dreveny, I., Deeves, S.E., Yue, B., Heery, D.M.
+==Function==
+[[http://www.uniprot.org/uniprot/KAT6A_HUMAN KAT6A_HUMAN]] Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2.<ref>PMID:11742995</ref> <ref>PMID:11965546</ref> <ref>PMID:12771199</ref> <ref>PMID:16387653</ref> <ref>PMID:17925393</ref>
-Description: Crystal Structure of MOZ double PHD finger histone H3 tail complex
+==About this Structure==
+[[4lk9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LK9 OCA].
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Histone acetyltransferase]]
+[[Category: Homo sapiens]]
+[[Category: Deeves, S E.]]
+[[Category: Dreveny, I.]]
+[[Category: Heery, D M.]]
+[[Category: Yue, B.]]
+[[Category: Double phd finger]]
+[[Category: Dpf]]
+[[Category: H3 tail]]
+[[Category: Histone acetyltransferase]]
+[[Category: Histone h3]]
+[[Category: Plant homeodomain finger]]
+[[Category: Transferase]]
+[[Category: Zinc finger]]