4m5z: Difference between revisions
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{{STRUCTURE_4m5z| PDB=4m5z | SCENE= }} | |||
===Crystal structure of broadly neutralizing antibody 5J8 bound to 2009 pandemic influenza hemagglutinin, HA1 subunit=== | |||
{{ABSTRACT_PUBMED_24027321}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/G8XMJ2_9INFA G8XMJ2_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS013827_004_327643] | |||
==About this Structure== | |||
[[4m5z]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M5Z OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024027321</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Influenza a virus]] | |||
[[Category: Hong, M.]] | |||
[[Category: Lee, P S.]] | |||
[[Category: Wilson, I A.]] | |||
[[Category: Hemagglutinin]] | |||
[[Category: Immunoglobulin fold]] | |||
[[Category: Viral protein-immune system complex]] | |||
