2nn1: Difference between revisions

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[[Image:2nn1.gif|left|200px]]<br /><applet load="2nn1" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2nn1.gif|left|200px]]
caption="2nn1, resolution 1.650&Aring;" />
 
'''Structure of inhibitor binding to Carbonic Anhydrase I'''<br />
{{Structure
|PDB= 2nn1 |SIZE=350|CAPTION= <scene name='initialview01'>2nn1</scene>, resolution 1.650&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=M28:3-[4-(AMINOSULFONYL)PHENYL]PROPANOIC+ACID'>M28</scene> and <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1]
|GENE= CA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Structure of inhibitor binding to Carbonic Anhydrase I'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2NN1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=NA:'>NA</scene>, <scene name='pdbligand=M28:'>M28</scene> and <scene name='pdbligand=TRS:'>TRS</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NN1 OCA].  
2NN1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NN1 OCA].  


==Reference==
==Reference==
Structural analysis of charge discrimination in the binding of inhibitors to human carbonic anhydrases I and II., Srivastava DK, Jude KM, Banerjee AL, Haldar M, Manokaran S, Kooren J, Mallik S, Christianson DW, J Am Chem Soc. 2007 May 2;129(17):5528-37. Epub 2007 Apr 4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17407288 17407288]
Structural analysis of charge discrimination in the binding of inhibitors to human carbonic anhydrases I and II., Srivastava DK, Jude KM, Banerjee AL, Haldar M, Manokaran S, Kooren J, Mallik S, Christianson DW, J Am Chem Soc. 2007 May 2;129(17):5528-37. Epub 2007 Apr 4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17407288 17407288]
[[Category: Carbonate dehydratase]]
[[Category: Carbonate dehydratase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: zinc metalloenzyme]]
[[Category: zinc metalloenzyme]]


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