Sandbox Mati: Difference between revisions
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<scene name='43/437742/2yxj_glu/2'>two negativly charged residues</scene> Glu 96 and Glu 129. | <scene name='43/437742/2yxj_glu/2'>two negativly charged residues</scene> Glu 96 and Glu 129. | ||
Two <scene name='43/437742/2yxj_hydrophobic/1'>hydrophobic patches</scene> which include Phe 191 Val 141 and | Two <scene name='43/437742/2yxj_hydrophobic/1'>hydrophobic patches</scene> which include Phe 191 Val 141 and | ||
Ala 93 for one, and the other patch includes Phe 146 Val 126 and Leu 108. <scene name='43/437742/2yxj_space_fill_color_charged/1'> | Ala 93 for one, and the other patch includes Phe 146 Val 126 and Leu 108.Now one can look at the <scene name='43/437742/2yxj_space_fill_color_charged/1'>Overall</scene> picture that there is negatively charge residues "above" and "below" the lignd and a posite charge on the "right" and "left" of it. | ||
Revision as of 07:00, 28 August 2013
Bcl-Xl is a member of the Bcl-2 family . This family consists of pro-apoptotic and anti-apoptotic members. Bcl-Xl(in the image)
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,an anti apoptotic protein, binds pro apoptotic proteins like BAK and BAD thus inhibiting program cell death. Many cancer cells overexpress at least one of the anti-apoptotic members of this family , thus escaping apoptosis . Therefore these proteins are important targets for the development of new anti-cancer drugs.
the PDB file 2yxjshows the structure of Bcl-Xl and ABT 737. ABT 737 is a sub nano Molar inhibitor of Bcl-Xl. It binds Bcl-xl in the same position as BAK does as can be seen in 1bxl. Interestingly the interface of Bcl-Xl is almost symmetric. There are two positively charged residues Arg 100 and Arg 139. two negativly charged residues Glu 96 and Glu 129. Two hydrophobic patches which include Phe 191 Val 141 and Ala 93 for one, and the other patch includes Phe 146 Val 126 and Leu 108.Now one can look at the Overall picture that there is negatively charge residues "above" and "below" the lignd and a posite charge on the "right" and "left" of it.
