2no3: Difference between revisions

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[[Image:2no3.gif|left|200px]]<br /><applet load="2no3" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2no3.gif|left|200px]]
caption="2no3, resolution 3.20&Aring;" />
 
'''Novel 4-anilinopyrimidines as potent JNK1 Inhibitors'''<br />
{{Structure
|PDB= 2no3 |SIZE=350|CAPTION= <scene name='initialview01'>2no3</scene>, resolution 3.20&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=859:2-({2-[(3-HYDROXYPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)BENZAMIDE'>859</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24]
|GENE= MAPK8, JNK1, PRKM8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Novel 4-anilinopyrimidines as potent JNK1 Inhibitors'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2NO3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=859:'>859</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NO3 OCA].  
2NO3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NO3 OCA].  


==Reference==
==Reference==
Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies., Liu M, Wang S, Clampit JE, Gum RJ, Haasch DL, Rondinone CM, Trevillyan JM, Abad-Zapatero C, Fry EH, Sham HL, Liu G, Bioorg Med Chem Lett. 2007 Feb 1;17(3):668-72. Epub 2006 Nov 2. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17107797 17107797]
Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies., Liu M, Wang S, Clampit JE, Gum RJ, Haasch DL, Rondinone CM, Trevillyan JM, Abad-Zapatero C, Fry EH, Sham HL, Liu G, Bioorg Med Chem Lett. 2007 Feb 1;17(3):668-72. Epub 2006 Nov 2. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17107797 17107797]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Mitogen-activated protein kinase]]
[[Category: Mitogen-activated protein kinase]]
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[[Category: 859]]
[[Category: 859]]
[[Category: SO4]]
[[Category: SO4]]
[[Category: anilinopyrimidines jnk1 inhibitors]]
[[Category: anilinopyrimidines jnk1 inhibitor]]
[[Category: c-jun n-terminal kinase]]
[[Category: c-jun n-terminal kinase]]
[[Category: jnk1]]
[[Category: jnk1]]
[[Category: jnk1 inhibitors]]
[[Category: jnk1 inhibitor]]


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