2no0: Difference between revisions

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[[Image:2no0.jpg|left|200px]]<br /><applet load="2no0" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2no0.jpg|left|200px]]
caption="2no0, resolution 1.80&Aring;" />
 
'''C4S dCK variant of dCK in complex with gemcitabine+ADP'''<br />
{{Structure
|PDB= 2no0 |SIZE=350|CAPTION= <scene name='initialview01'>2no0</scene>, resolution 1.80&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=ADP:ADENOSINE-5'-DIPHOSPHATE'>ADP</scene> and <scene name='pdbligand=GEO:GEMCITABINE'>GEO</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Deoxycytidine_kinase Deoxycytidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.74 2.7.1.74]
|GENE= DCK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''C4S dCK variant of dCK in complex with gemcitabine+ADP'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2NO0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ADP:'>ADP</scene> and <scene name='pdbligand=GEO:'>GEO</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Deoxycytidine_kinase Deoxycytidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.74 2.7.1.74] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NO0 OCA].  
2NO0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NO0 OCA].  


==Reference==
==Reference==
Nonenantioselectivity Property of Human Deoxycytidine Kinase Explained by Structures of the Enzyme in Complex with l- and d-Nucleosides., Sabini E, Hazra S, Konrad M, Lavie A, J Med Chem. 2007 Jun 28;50(13):3004-14. Epub 2007 May 27. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17530837 17530837]
Nonenantioselectivity Property of Human Deoxycytidine Kinase Explained by Structures of the Enzyme in Complex with l- and d-Nucleosides., Sabini E, Hazra S, Konrad M, Lavie A, J Med Chem. 2007 Jun 28;50(13):3004-14. Epub 2007 May 27. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17530837 17530837]
[[Category: Deoxycytidine kinase]]
[[Category: Deoxycytidine kinase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: human deoxycytidine kinase]]
[[Category: human deoxycytidine kinase]]


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