4aur: Difference between revisions
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==LeoA bacterial dynamin GTPase from ETEC== | |||
===LeoA bacterial dynamin | <StructureSection load='4aur' size='340' side='right' caption='[[4aur]], [[Resolution|resolution]] 2.70Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4aur]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoh1 Ecoh1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AUR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AUR FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aur OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4aur RCSB], [http://www.ebi.ac.uk/pdbsum/4aur PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Escherichia coli (ETEC) strain H10407 contains a GTPase virulence factor, LeoA, which is encoded on a pathogenicity island and has been shown to enhance toxin release, potentially through vesicle secretion. By sequence comparisons and X-ray structure determination we now identify LeoA as a bacterial dynamin-like protein (DLP). Proteins of the dynamin family remodel membranes and were once thought to be restricted to eukaryotes. In ETEC H10407 LeoA localises to the periplasm where it forms a punctate localisation pattern. Bioinformatic analyses of leoA and the two upstream genes leoB and leoC suggest that LeoA works in concert with a second dynamin-like protein, made up of LeoB and LeoC. Disruption of the leoAB genes leads to a reduction in secretion of periplasmic Tat-GFP and outer membrane OmpA. Our data suggest a role for LeoABC dynamin-like proteins in potentiating virulence through membrane vesicle associated toxin secretion. | |||
LeoA, B and C from Enterotoxigenic Escherichia coli (ETEC) Are Bacterial Dynamins.,Michie KA, Boysen A, Low HH, Moller-Jensen J, Lowe J PLoS One. 2014 Sep 9;9(9):e107211. doi: 10.1371/journal.pone.0107211. eCollection, 2014. PMID:25203511<ref>PMID:25203511</ref> | |||
[[Category: | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Ecoh1]] | |||
[[Category: Low, H H.]] | [[Category: Low, H H.]] | ||
[[Category: Lowe, J.]] | [[Category: Lowe, J.]] | ||
Revision as of 08:15, 22 October 2014
LeoA bacterial dynamin GTPase from ETEC
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