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| {{STRUCTURE_4gse| PDB=4gse | SCENE= }}
| | #REDIRECT [[4ifh]] This PDB entry is obsolete and replaced by 4ifh |
| ===Structure analysis of cysteine-free insulin degrading enzyme with BDM-44619, 4-methyl-N-({1-[(2S)-1-(naphthalen-2-yl)-4-nitroso-4-oxobutan-2-yl]-1H- 1,2,3-Triazol-4-yl}methyl)benzamide===
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| ==Function==
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| [[http://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN]] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref> | |
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| ==About this Structure==
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| [[4gse]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GSE OCA].
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| ==Reference==
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| <references group="xtra"/><references/>
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| [[Category: Homo sapiens]]
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| [[Category: Insulysin]]
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| [[Category: Deprez, B.]]
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| [[Category: Deprez-Poulain, R.]]
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| [[Category: Guo, Q.]]
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| [[Category: Tang, W J.]]
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| [[Category: Hydrolase]]
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| [[Category: Hydrolase-hydrolase inhibitor complex]]
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| [[Category: Insulin degrading enzyme]]
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