3hj3: Difference between revisions
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{{STRUCTURE_3hj3| PDB=3hj3 | SCENE= }} | {{STRUCTURE_3hj3| PDB=3hj3 | SCENE= }} | ||
===Crystal Structure of the ChTS-DHFR F207A Non-Active Site Mutant=== | ===Crystal Structure of the ChTS-DHFR F207A Non-Active Site Mutant=== | ||
{{ABSTRACT_PUBMED_24324854}} | |||
==Function== | ==Function== | ||
| Line 6: | Line 7: | ||
==About this Structure== | ==About this Structure== | ||
[[3hj3]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[3hj3]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Cryho Cryho]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HJ3 OCA]. | ||
==See Also== | ==See Also== | ||
*[[Thymidylate synthase|Thymidylate synthase]] | *[[Thymidylate synthase|Thymidylate synthase]] | ||
[[Category: | |||
==Reference== | |||
<ref group="xtra">PMID:024324854</ref><references group="xtra"/><references/> | |||
[[Category: Cryho]] | |||
[[Category: Anderson, K S.]] | [[Category: Anderson, K S.]] | ||
[[Category: Martucci, W E.]] | [[Category: Martucci, W E.]] | ||
Revision as of 06:44, 15 January 2014
Crystal Structure of the ChTS-DHFR F207A Non-Active Site Mutant
Template:ABSTRACT PUBMED 24324854
Function
[Q5CGA3_CRYHO] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism (By similarity).[PIRNR:PIRNR000389]
About this Structure
3hj3 is a 4 chain structure with sequence from Cryho. Full crystallographic information is available from OCA.
See Also
Reference
- Martucci WE, Rodriguez JM, Vargo MA, Marr M, Hamilton AD, Anderson KS. Exploring novel strategies for AIDS protozoal pathogens: alpha-helix mimetics targeting a key allosteric protein-protein interaction in TS-DHFR. Medchemcomm. 2013 Sep;4(9). doi: 10.1039/C3MD00141E. PMID:24324854 doi:https://dx.doi.org/10.1039/C3MD00141E
