2nsh: Difference between revisions

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[[Image:2nsh.gif|left|200px]]<br /><applet load="2nsh" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2nsh.gif|left|200px]]
caption="2nsh, resolution 1.80&Aring;" />
 
'''E. coli PurE H45Q mutant complexed with nitro-AIR'''<br />
{{Structure
|PDB= 2nsh |SIZE=350|CAPTION= <scene name='initialview01'>2nsh</scene>, resolution 1.80&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=NIA:((2R,3S,4R,5R)-5-(5-AMINO-4-NITRO-1H-IMIDAZOL-1-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL)METHYL DIHYDROGEN PHOSPHATE'>NIA</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Phosphoribosylaminoimidazole_carboxylase Phosphoribosylaminoimidazole carboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.21 4.1.1.21]
|GENE= purE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
}}
 
'''E. coli PurE H45Q mutant complexed with nitro-AIR'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2NSH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=NIA:'>NIA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Phosphoribosylaminoimidazole_carboxylase Phosphoribosylaminoimidazole carboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.21 4.1.1.21] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NSH OCA].  
2NSH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NSH OCA].  


==Reference==
==Reference==
N5-CAIR mutase: role of a CO2 binding site and substrate movement in catalysis., Hoskins AA, Morar M, Kappock TJ, Mathews II, Zaugg JB, Barder TE, Peng P, Okamoto A, Ealick SE, Stubbe J, Biochemistry. 2007 Mar 13;46(10):2842-55. Epub 2007 Feb 14. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17298082 17298082]
N5-CAIR mutase: role of a CO2 binding site and substrate movement in catalysis., Hoskins AA, Morar M, Kappock TJ, Mathews II, Zaugg JB, Barder TE, Peng P, Okamoto A, Ealick SE, Stubbe J, Biochemistry. 2007 Mar 13;46(10):2842-55. Epub 2007 Feb 14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17298082 17298082]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Phosphoribosylaminoimidazole carboxylase]]
[[Category: Phosphoribosylaminoimidazole carboxylase]]
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[[Category: kinked c-terminal helix]]
[[Category: kinked c-terminal helix]]


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