4gg2: Difference between revisions

Line 1:

~~'''Unreleased~~ structure~~'''~~

===The crystal structure of glutamate-bound human gamma-glutamyltranspeptidase 1===

The entry ~~4gg2 is ON HOLD until Sep 30 2014~~

==Disease==

[[http://www.uniprot.org/uniprot/GGT1_HUMAN GGT1_HUMAN]] Gamma-glutamyl transpeptidase deficiency. The disease is caused by mutations affecting the gene represented in this entry.

~~Authors~~: ~~West, M~~.B., ~~Chen, Y~~.~~, Wickham, S~~.~~, Heroux, A~~., ~~Cahill, K~~.~~, Hanigan, M.H., Mooers, B.H.M~~.

==Function==

[[http://www.uniprot.org/uniprot/GGT1_HUMAN GGT1_HUMAN]] Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive.<ref>PMID:7689219</ref> <ref>PMID:20622017</ref>

~~Description~~: ~~The crystal structure of glutamate~~-~~bound human~~-~~glutamyltranspeptidase 1~~

==About this Structure==

[[4gg2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Zasmidium_angulare Zasmidium angulare]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GG2 OCA].

==Reference==

[[Category: Homo sapiens]]

[[Category: Zasmidium angulare]]

[[Category: Cahill, K.]]

[[Category: Chen, Y.]]

[[Category: Hanigan, M H.]]

[[Category: Heroux, A.]]

[[Category: Mooers, B H.M.]]

[[Category: West, M B.]]

[[Category: Wickham, S.]]

[[Category: Exterior cell surface]]

[[Category: Glutathionine metabolism]]

[[Category: Hydrolase]]

[[Category: N-glycosylation]]

[[Category: Ntn-hydrolyase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4gg2|  PDB=4gg2  |  SCENE=  }}
+===The crystal structure of glutamate-bound human gamma-glutamyltranspeptidase 1===
-The entry 4gg2 is ON HOLD  until Sep 30 2014
+==Disease==
+[[http://www.uniprot.org/uniprot/GGT1_HUMAN GGT1_HUMAN]] Gamma-glutamyl transpeptidase deficiency. The disease is caused by mutations affecting the gene represented in this entry.
-Authors: West, M.B., Chen, Y., Wickham, S., Heroux, A., Cahill, K., Hanigan, M.H., Mooers, B.H.M.
+==Function==
+[[http://www.uniprot.org/uniprot/GGT1_HUMAN GGT1_HUMAN]] Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive.<ref>PMID:7689219</ref> <ref>PMID:20622017</ref>
-Description: The crystal structure of glutamate-bound human-glutamyltranspeptidase 1
+==About this Structure==
+[[4gg2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Zasmidium_angulare Zasmidium angulare]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GG2 OCA].
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Zasmidium angulare]]
+[[Category: Cahill, K.]]
+[[Category: Chen, Y.]]
+[[Category: Hanigan, M H.]]
+[[Category: Heroux, A.]]
+[[Category: Mooers, B H.M.]]
+[[Category: West, M B.]]
+[[Category: Wickham, S.]]
+[[Category: Exterior cell surface]]
+[[Category: Glutathionine metabolism]]
+[[Category: Hydrolase]]
+[[Category: N-glycosylation]]
+[[Category: Ntn-hydrolyase]]