4ln7: Difference between revisions
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{{STRUCTURE_4ln7| PDB=4ln7 | SCENE= }} | |||
===5,6-bis(4-fluorophenyl)-3-hydroxy-2,5-dihydropyridin-2-one bound to influenza 2009 pH1N1 endonuclease=== | |||
{{ABSTRACT_PUBMED_23978130}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/F0TRT1_9INFA F0TRT1_9INFA]] Implicated in endonuclease cleavage of capped RNA primers. Displays an elongation factor activity in viral RNA synthesis. Dispensable for viral transcription, but not replication (By similarity).[SAAS:SAAS001009_004_020464] | |||
==About this Structure== | |||
[[4ln7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/lima/wrair1695p/2009(h1n1)) Influenza a virus (a/lima/wrair1695p/2009(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LN7 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023978130</ref><references group="xtra"/><references/> | |||
[[Category: Arnold, E.]] | |||
[[Category: Bauman, J D.]] | |||
[[Category: Das, K.]] | |||
[[Category: Patel, D.]] | |||
[[Category: Cap-snatching]] | |||
[[Category: Rna binding protein-inhibitor]] | |||
[[Category: Rna binding protein-inhibitor complex]] | |||
Revision as of 04:15, 20 September 2013
5,6-bis(4-fluorophenyl)-3-hydroxy-2,5-dihydropyridin-2-one bound to influenza 2009 pH1N1 endonuclease
Template:ABSTRACT PUBMED 23978130
Function
[F0TRT1_9INFA] Implicated in endonuclease cleavage of capped RNA primers. Displays an elongation factor activity in viral RNA synthesis. Dispensable for viral transcription, but not replication (By similarity).[SAAS:SAAS001009_004_020464]
About this Structure
4ln7 is a 1 chain structure with sequence from Influenza a virus (a/lima/wrair1695p/2009(h1n1)). Full crystallographic information is available from OCA.
Reference
- Bauman JD, Patel D, Baker SF, Vijayan RS, Xiang A, Parhi AK, Martinez-Sobrido L, Lavoie EJ, Das K, Arnold E. Crystallographic Fragment Screening and Structure-Based Optimization Yields a New Class of Influenza Endonuclease Inhibitors. ACS Chem Biol. 2013 Sep 13. PMID:23978130 doi:10.1021/cb400400j
