4l5l: Difference between revisions

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{{STRUCTURE_4l5l|  PDB=4l5l  |  SCENE=  }}
==Crystal structure of 26 kDa GST of Clonorchis sinensis in P212121 symmetry==
===Crystal structure of 26 kDa GST of Clonorchis sinensis in P212121 symmetry===
<StructureSection load='4l5l' size='340' side='right' caption='[[4l5l]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
{{ABSTRACT_PUBMED_23916611}}
== Structural highlights ==
<table><tr><td colspan='2'>[[4l5l]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Clonorchis_sinensis Clonorchis sinensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L5L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L5L FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3iso|3iso]], [[4l5o|4l5o]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l5l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l5l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l5l RCSB], [http://www.ebi.ac.uk/pdbsum/4l5l PDBsum]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The crystal structures of CsGST in two different space groups revealed that Asp26 and His79 coordinate a zinc ion. In one space group, His46 of an adjacent molecule participates in the coordination within 2.0A. In the other space group, Asp26, His79 and a water molecule coordinate a zinc ion. The CsGST-D26H structure showed that four histidine residues - His26 and His79 from one molecule and the same residues from a symmetry-related neighboring molecule - coordinate a zinc ion. The coordinated zinc ions are located between two molecules and mediate molecular contacts within the crystal.


==About this Structure==
Crystal structures of 26kDa Clonorchis sinensis glutathione S-transferase reveal zinc binding and putative metal binding.,Han YH, Hong SJ, Cheong HK, Chung YJ Biochem Biophys Res Commun. 2013 Aug 23;438(2):457-61. doi:, 10.1016/j.bbrc.2013.07.102. Epub 2013 Jul 31. PMID:23916611<ref>PMID:23916611</ref>
[[4l5l]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Clonorchis_sinensis Clonorchis sinensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L5L OCA].


==Reference==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
<ref group="xtra">PMID:023916611</ref><references group="xtra"/><references/>
</div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Clonorchis sinensis]]
[[Category: Clonorchis sinensis]]
[[Category: Chung, Y J.]]
[[Category: Chung, Y J]]
[[Category: Han, Y H.]]
[[Category: Han, Y H]]
[[Category: Gsh binding]]
[[Category: Gsh binding]]
[[Category: Transferase]]
[[Category: Transferase]]
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