4kek: Difference between revisions
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===Crystal structure of mouse Ryanodine Receptor 2 (1-217) disease mutant R176Q=== | ===Crystal structure of mouse Ryanodine Receptor 2 (1-217) disease mutant R176Q=== | ||
{{ABSTRACT_PUBMED_23978697}} | {{ABSTRACT_PUBMED_23978697}} | ||
==Function== | |||
[[http://www.uniprot.org/uniprot/RYR2_MOUSE RYR2_MOUSE]] Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.<ref>PMID:10473538</ref> <ref>PMID:9628868</ref> <ref>PMID:21098440</ref> <ref>PMID:20431056</ref> | |||
==About this Structure== | ==About this Structure== | ||
