3wgp: Difference between revisions

Line 1:

'''~~Unreleased~~ structure'''

==Crystal Structure Analysis of Vitamin D receptor==

~~The~~ entry ~~3wgp is ON HOLD~~

== Structural highlights ==

<table><tr><td colspan='2'>[[3wgp]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WGP OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WGP FirstGlance].

~~Authors~~: ~~Itoh~~, S., Iijima, S.

</td></tr><tr><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=ED9:(1R,2R,3R,5Z,7E,14BETA,17ALPHA)-2-(3-HYDROXYPROPOXY)-9,10-SECOCHOLESTA-5,7,10-TRIENE-1,3,25-TRIOL'>ED9</scene>

<tr><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wgp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wgp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wgp RCSB], [http://www.ebi.ac.uk/pdbsum/3wgp PDBsum]</td></tr>

~~Description~~: ~~Crystal Structure Analysis of Vitamin D~~ receptor

<table>

== Disease ==

[[http://www.uniprot.org/uniprot/VDR_HUMAN VDR_HUMAN]] Defects in VDR are the cause of rickets vitamin D-dependent type 2A (VDDR2A) [MIM:[http://omim.org/entry/277440 277440]]. A disorder of vitamin D metabolism resulting in severe rickets, hypocalcemia and secondary hyperparathyroidism. Most patients have total alopecia in addition to rickets.<ref>PMID:2849209</ref> <ref>PMID:8381803</ref> <ref>PMID:1652893</ref> <ref>PMID:2177843</ref> <ref>PMID:8106618</ref> <ref>PMID:8392085</ref> <ref>PMID:7828346</ref> <ref>PMID:8675579</ref> <ref>PMID:8961271</ref> <ref>PMID:9005998</ref>

== Function ==

[[http://www.uniprot.org/uniprot/VDR_HUMAN VDR_HUMAN]] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.<ref>PMID:16252006</ref> <ref>PMID:10678179</ref> <ref>PMID:15728261</ref> <ref>PMID:16913708</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Iijima, S.]]

[[Category: Itoh, S.]]

[[Category: Hormone receptor]]

[[Category: Steroid hormon receptor family member]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Crystal Structure Analysis of Vitamin D receptor==
+<StructureSection load='3wgp' size='340' side='right' caption='[[3wgp]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-The entry 3wgp is ON HOLD
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3wgp]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WGP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WGP FirstGlance]. <br>
-Authors: Itoh, S., Iijima, S.
+</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ED9:(1R,2R,3R,5Z,7E,14BETA,17ALPHA)-2-(3-HYDROXYPROPOXY)-9,10-SECOCHOLESTA-5,7,10-TRIENE-1,3,25-TRIOL'>ED9</scene><br>
+<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wgp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wgp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wgp RCSB], [http://www.ebi.ac.uk/pdbsum/3wgp PDBsum]</span></td></tr>
-Description: Crystal Structure Analysis of Vitamin D receptor
+<table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/VDR_HUMAN VDR_HUMAN]] Defects in VDR are the cause of rickets vitamin D-dependent type 2A (VDDR2A) [MIM:[http://omim.org/entry/277440 277440]]. A disorder of vitamin D metabolism resulting in severe rickets, hypocalcemia and secondary hyperparathyroidism. Most patients have total alopecia in addition to rickets.<ref>PMID:2849209</ref> <ref>PMID:8381803</ref> <ref>PMID:1652893</ref> <ref>PMID:2177843</ref> <ref>PMID:8106618</ref> <ref>PMID:8392085</ref> <ref>PMID:7828346</ref> <ref>PMID:8675579</ref> <ref>PMID:8961271</ref> <ref>PMID:9005998</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/VDR_HUMAN VDR_HUMAN]] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.<ref>PMID:16252006</ref> <ref>PMID:10678179</ref> <ref>PMID:15728261</ref> <ref>PMID:16913708</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Iijima, S.]]
+[[Category: Itoh, S.]]
+[[Category: Hormone receptor]]
+[[Category: Steroid hormon receptor family member]]