3wi2: Difference between revisions
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{{STRUCTURE_3wi2| PDB=3wi2 | SCENE= }} | |||
===Crystal structure of PDE10A in complex with inhibitor=== | |||
{{ABSTRACT_PUBMED_24238902}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref> | |||
==About this Structure== | |||
[[3wi2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WI2 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024238902</ref><references group="xtra"/><references/> | |||
[[Category: Amano, Y.]] | |||
[[Category: Cgmp binding]] | |||
[[Category: Hydrolase-hydrolase inhibitor complex]] | |||
[[Category: Phosphodiesterase]] | |||