4mjc: Difference between revisions
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''' | ==Synechocystis sp. PCC 6803 glutaredoxin A - P84R== | ||
<StructureSection load='4mjc' size='340' side='right' caption='[[4mjc]], [[Resolution|resolution]] 1.41Å' scene=''> | |||
== Structural highlights == | |||
[[4mjc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MJC OCA]. <br> | |||
<b>Related:</b> [[3qmx|3qmx]], [[4mja|4mja]], [[4mjb|4mjb]], [[4mje|4mje]]<br> | |||
<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br> | |||
== Publication Abstract from PubMed == | |||
Glutaredoxin from the cyanobacterium Synechocystis sp. PCC 6803 is a small protein, containing only 88 amino acids, that participates in a large number of redox reactions, serving both as an electron donor for enzyme-catalyzed reductions and as a regulator of diverse metabolic pathways. The crystal structures of glutaredoxins from several species have been solved, including the glutaredoxin A isoform from the cyanobacterium Synechocystis sp. PCC 6803. We have utilized the small size of Synechocystis glutaredoxin A and its propensity to form protein crystals that diffract to high resolution to explore a long-standing question in biochemistry; i.e., what are the effects of mutations on protein structure and function? Taking advantage of these properties, we have initiated a long-term educational project that would examine the structural and biochemical changes in glutaredoxin as a function of single-point mutational replacements. Here, we report some of the mutational effects that we have observed to date. | |||
Utility of Synechocystis sp. PCC 6803 glutaredoxin A as a platform to study high-resolution mutagenesis of proteins.,Knaff DB, Sutton RB Front Plant Sci. 2013 Nov 15;4:461. doi: 10.3389/fpls.2013.00461. eCollection, 2013. PMID:24298277<ref>PMID:24298277</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Knaff, D B.]] | |||
[[Category: Sutton, R B.]] | |||
[[Category: Electron transport]] | |||
[[Category: Oxidation/reduction]] | |||
[[Category: Thioredoxin fold]] | |||
Revision as of 07:50, 30 April 2014
Synechocystis sp. PCC 6803 glutaredoxin A - P84R
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