4mk0: Difference between revisions

Line 1:

~~'''Unreleased~~ structure~~'''~~

===Crystal structure of G protein-coupled receptor kinase 2 in complex with a a rationally designed paroxetine derivative===

The ~~entry 4mk0 is ON HOLD~~

==Function==

[[http://www.uniprot.org/uniprot/ARBK1_HUMAN ARBK1_HUMAN]] Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.<ref>PMID:19306925</ref> [[http://www.uniprot.org/uniprot/GBG2_BOVIN GBG2_BOVIN]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. [[http://www.uniprot.org/uniprot/GBB1_BOVIN GBB1_BOVIN]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

~~Authors~~: ~~Homan, K.T~~.~~, Tesmer, J~~.J.G.

==About this Structure==

[[4mk0]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MK0 OCA].

~~Description~~: ~~Crystal structure of~~ G protein-~~coupled receptor kinase 2 in~~ complex ~~with a a rationally designed paroxetine derivative~~

==Reference==

[[Category: Homan, K T.]]

[[Category: Tesmer, J J.G.]]

[[Category: Atp binding]]

[[Category: Hydrolase]]

[[Category: Inhibitor complex]]

[[Category: Peripheral membrane protein]]

[[Category: Phosphorylation]]

[[Category: Protein kinase]]

[[Category: Signaling protein-inhibitor complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4mk0|  PDB=4mk0  |  SCENE=  }}
+===Crystal structure of G protein-coupled receptor kinase 2 in complex with a a rationally designed paroxetine derivative===
+{{ABSTRACT_PUBMED_24220010}}
-The entry 4mk0 is ON HOLD
+==Function==
+[[http://www.uniprot.org/uniprot/ARBK1_HUMAN ARBK1_HUMAN]] Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.<ref>PMID:19306925</ref>  [[http://www.uniprot.org/uniprot/GBG2_BOVIN GBG2_BOVIN]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. [[http://www.uniprot.org/uniprot/GBB1_BOVIN GBB1_BOVIN]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
-Authors: Homan, K.T., Tesmer, J.J.G.
+==About this Structure==
+[[4mk0]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MK0 OCA].
-Description: Crystal structure of G protein-coupled receptor kinase 2 in complex with a a rationally designed paroxetine derivative
+==Reference==
+<ref group="xtra">PMID:024220010</ref><references group="xtra"/><references/>
+[[Category: Homan, K T.]]
+[[Category: Tesmer, J J.G.]]
+[[Category: Atp binding]]
+[[Category: Hydrolase]]
+[[Category: Inhibitor complex]]
+[[Category: Peripheral membrane protein]]
+[[Category: Phosphorylation]]
+[[Category: Protein kinase]]
+[[Category: Signaling protein-inhibitor complex]]