2o4s: Difference between revisions

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[[Image:2o4s.gif|left|200px]]~~<br /><applet load~~="2o4s~~" size~~="350~~" color~~=~~"white" frame~~=~~"true" align="right" spinBox="true"~~

[[Image:2o4s.gif|left|200px]]

~~caption="~~2o4s, resolution 1.540Å" />

'''Crystal Structure of HIV-1 Protease (Q7K) in Complex with Lopinavir'''~~<br />~~

{{Structure

|PDB= 2o4s |SIZE=350|CAPTION= <scene name='initialview01'>2o4s</scene>, resolution 1.540Å

|SITE=

|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=AB1:N-{1-BENZYL-4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-5-PHENYL-PENTYL}-3-METHYL-2-(2-OXO-TETRAHYDRO-PYRIMIDIN-1-YL)-BUTYRAMIDE'>AB1</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>

|ACTIVITY=

|GENE= gag-pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])

}}

'''Crystal Structure of HIV-1 Protease (Q7K) in Complex with Lopinavir'''

==Overview==

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==About this Structure==

2O4S is a [~~http://en.wikipedia.org/wiki/Single_protein~~ Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1~~] with <scene name='pdbligand=CL:'>CL</scene>, <scene name='pdbligand=AB1:'>AB1</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O4S OCA].

2O4S is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O4S OCA].

==Reference==

Unique thermodynamic response of tipranavir to human immunodeficiency virus type 1 protease drug resistance mutations., Muzammil S, Armstrong AA, Kang LW, Jakalian A, Bonneau PR, Schmelmer V, Amzel LM, Freire E, J Virol. 2007 May;81(10):5144-54. Epub 2007 Mar 14. PMID:[http://~~ispc~~.~~weizmann~~.ac.~~il/~~/~~pmbin~~/~~getpm?pmid=~~17360759 17360759]

Unique thermodynamic response of tipranavir to human immunodeficiency virus type 1 protease drug resistance mutations., Muzammil S, Armstrong AA, Kang LW, Jakalian A, Bonneau PR, Schmelmer V, Amzel LM, Freire E, J Virol. 2007 May;81(10):5144-54. Epub 2007 Mar 14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17360759 17360759]

[[Category: Human immunodeficiency virus 1]]

[[Category: Single protein]]

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[[Category: protease]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:55:04 2008''

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@@ Line 1: / Line 1: @@
-[[Image:2o4s.gif|left|200px]]<br /><applet load="2o4s" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:2o4s.gif|left|200px]]
-caption="2o4s, resolution 1.540&Aring;" />
-'''Crystal Structure of HIV-1 Protease (Q7K) in Complex with Lopinavir'''<br />
+ {{Structure
+|PDB= 2o4s |SIZE=350|CAPTION= <scene name='initialview01'>2o4s</scene>, resolution 1.540&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=AB1:N-{1-BENZYL-4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-5-PHENYL-PENTYL}-3-METHYL-2-(2-OXO-TETRAHYDRO-PYRIMIDIN-1-YL)-BUTYRAMIDE'>AB1</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
+|ACTIVITY=
+|GENE= gag-pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])
+}}
+'''Crystal Structure of HIV-1 Protease (Q7K) in Complex with Lopinavir'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-O4S is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=CL:'>CL</scene>, <scene name='pdbligand=AB1:'>AB1</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O4S OCA].
+O4S is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O4S OCA].
 ==Reference==
-Unique thermodynamic response of tipranavir to human immunodeficiency virus type 1 protease drug resistance mutations., Muzammil S, Armstrong AA, Kang LW, Jakalian A, Bonneau PR, Schmelmer V, Amzel LM, Freire E, J Virol. 2007 May;81(10):5144-54. Epub 2007 Mar 14. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17360759 17360759]
+Unique thermodynamic response of tipranavir to human immunodeficiency virus type 1 protease drug resistance mutations., Muzammil S, Armstrong AA, Kang LW, Jakalian A, Bonneau PR, Schmelmer V, Amzel LM, Freire E, J Virol. 2007 May;81(10):5144-54. Epub 2007 Mar 14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17360759 17360759]
 [[Category: Human immunodeficiency virus 1]]
 [[Category: Single protein]]
@@ Line 25: / Line 34: @@
 [[Category: protease]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:14:23 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:55:04 2008''