2lwk: Difference between revisions

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~~{{STRUCTURE_2lwk| PDB=2lwk | SCENE= }}~~

==Solution structure of small molecule-influenza RNA complex==

===Solution structure of small molecule-influenza RNA complex===

== Structural highlights ==

<table><tr><td colspan='2'>[[2lwk]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LWK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LWK FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0EC:6,7-DIMETHOXY-2-(PIPERAZIN-1-YL)QUINAZOLIN-4-AMINE'>0EC</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lwk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lwk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lwk RCSB], [http://www.ebi.ac.uk/pdbsum/2lwk PDBsum]</span></td></tr>

</table>

== Publication Abstract from PubMed ==

Through screening by NMR spectroscopy, we discovered a novel scaffold (DPQ: 6,7-dimethoxy-2-(1-piperazinyl)-4-quinazolinamine) that binds specifically to the influenza A virus RNA promoter. The solution structure of the RNA-DPQ complex reported here demonstrates that the internal loop is the binding site of DPQ. The scaffold exhibits antiviral activity against influenza viruses.

~~==About this Structure==~~

A novel small-molecule binds to the influenza A virus RNA promoter and inhibits viral replication.,Lee MK, Bottini A, Kim M, Bardaro MF Jr, Zhang Z, Pellecchia M, Choi BS, Varani G Chem Commun (Camb). 2014 Jan 11;50(3):368-70. doi: 10.1039/c3cc46973e. Epub 2013 , Nov 18. PMID:24247110<ref>PMID:24247110</ref>

~~[[2lwk]] is a 1 chain structure~~. ~~Full experimental information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin~~/~~ocashort?id=2LWK OCA].~~

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

</div>

== References ==

__TOC__

</StructureSection>

[[Category: Choi, B S.]]

[[Category: Lee, M K.]]

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@@ Line 1: / Line 1: @@
-{{STRUCTURE_2lwk|  PDB=2lwk  |  SCENE=  }}
+==Solution structure of small molecule-influenza RNA complex==
-===Solution structure of small molecule-influenza RNA complex===
+<StructureSection load='2lwk' size='340' side='right' caption='[[2lwk]], [[NMR_Ensembles_of_Models | 16 NMR models]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2lwk]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LWK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LWK FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0EC:6,7-DIMETHOXY-2-(PIPERAZIN-1-YL)QUINAZOLIN-4-AMINE'>0EC</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lwk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lwk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lwk RCSB], [http://www.ebi.ac.uk/pdbsum/2lwk PDBsum]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Through screening by NMR spectroscopy, we discovered a novel scaffold (DPQ: 6,7-dimethoxy-2-(1-piperazinyl)-4-quinazolinamine) that binds specifically to the influenza A virus RNA promoter. The solution structure of the RNA-DPQ complex reported here demonstrates that the internal loop is the binding site of DPQ. The scaffold exhibits antiviral activity against influenza viruses.
-==About this Structure==
+A novel small-molecule binds to the influenza A virus RNA promoter and inhibits viral replication.,Lee MK, Bottini A, Kim M, Bardaro MF Jr, Zhang Z, Pellecchia M, Choi BS, Varani G Chem Commun (Camb). 2014 Jan 11;50(3):368-70. doi: 10.1039/c3cc46973e. Epub 2013 , Nov 18. PMID:24247110<ref>PMID:24247110</ref>
-[[2lwk]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LWK OCA].
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Choi, B S.]]
 [[Category: Lee, M K.]]