4bhd: Difference between revisions
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{{STRUCTURE_4bhd| PDB=4bhd | SCENE= }} | |||
===Methanococcus jannaschii serine hydroxymethyl-transferase, apo form=== | |||
The | ==Function== | ||
[[http://www.uniprot.org/uniprot/GLYA_METJA GLYA_METJA]] Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. The use of tetrahydrofolate (THF or H4PteGlu) as the pteridine substrate is 450-fold less efficient than that of H4MPT. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. Thus, is able to catalyze the cleavage of L-allo-threonine and L-threo-beta-phenylserine.<ref>PMID:12902326</ref> | |||
==About this Structure== | |||
[[4bhd]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BHD OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Angelucci, F.]] | |||
[[Category: Ilari, A.]] | |||
[[Category: Saccoccia, F.]] | |||
[[Category: Transferase]] | |||
Revision as of 09:58, 16 April 2014
Methanococcus jannaschii serine hydroxymethyl-transferase, apo form
Function
[GLYA_METJA] Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. The use of tetrahydrofolate (THF or H4PteGlu) as the pteridine substrate is 450-fold less efficient than that of H4MPT. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. Thus, is able to catalyze the cleavage of L-allo-threonine and L-threo-beta-phenylserine.[1]
About this Structure
4bhd is a 2 chain structure. Full crystallographic information is available from OCA.
Reference
- ↑ Angelaccio S, Chiaraluce R, Consalvi V, Buchenau B, Giangiacomo L, Bossa F, Contestabile R. Catalytic and thermodynamic properties of tetrahydromethanopterin-dependent serine hydroxymethyltransferase from Methanococcus jannaschii. J Biol Chem. 2003 Oct 24;278(43):41789-97. Epub 2003 Aug 5. PMID:12902326 doi:https://dx.doi.org/10.1074/jbc.M306747200
