4c50: Difference between revisions

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'''Unreleased structure'''
{{STRUCTURE_4c50|  PDB=4c50  |  SCENE=  }}
===Crystal Structure of the Catalase-Peroxidase (KatG) D137S mutant from Mycobacterium Tuberculosis===
{{ABSTRACT_PUBMED_24185282}}


The entry 4c50 is ON HOLD until Paper Publication
==Function==
[[http://www.uniprot.org/uniprot/KATG_MYCTU KATG_MYCTU]] Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. Displays also NADH oxidase, isoniazid (INH) lyase and isonicotinoyl-NAD synthase activity. May play a role in the intracellular survival of mycobacteria. May be involved in DNA repair. Partly complements recA-deficient E.coli cells exposed to UV radiation, mitomycin C or hydrogen peroxide. Increases resistance to mitomycin C in E.coli cells deficient for either uvrA, uvrB or uvrC.<ref>PMID:10463167</ref>  


Authors: Hersleth, H.-P., Zhao, X., Magliozzo, R.S., Andersson, K.K.
==About this Structure==
[[4c50]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C50 OCA].  


Description: Crystal Structure of the Catalase-Peroxidase (KatG) D137S mutant from Mycobacterium Tuberculosis
==Reference==
<ref group="xtra">PMID:024185282</ref><references group="xtra"/><references/>
[[Category: Catalase peroxidase]]
[[Category: Andersson, K K.]]
[[Category: Hersleth, H P.]]
[[Category: Magliozzo, R S.]]
[[Category: Zhao, X.]]
[[Category: Oxidoreductase]]

Revision as of 08:20, 13 November 2013

Template:STRUCTURE 4c50

Crystal Structure of the Catalase-Peroxidase (KatG) D137S mutant from Mycobacterium Tuberculosis

Template:ABSTRACT PUBMED 24185282

Function

[KATG_MYCTU] Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. Displays also NADH oxidase, isoniazid (INH) lyase and isonicotinoyl-NAD synthase activity. May play a role in the intracellular survival of mycobacteria. May be involved in DNA repair. Partly complements recA-deficient E.coli cells exposed to UV radiation, mitomycin C or hydrogen peroxide. Increases resistance to mitomycin C in E.coli cells deficient for either uvrA, uvrB or uvrC.[1]

About this Structure

4c50 is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  1. Zhao X, Hersleth HP, Zhu J, Andersson KK, Magliozzo RS. Access channel residues Ser315 and Asp137 in Mycobacterium tuberculosis catalase-peroxidase (KatG) control peroxidatic activation of the pro-drug isoniazid. Chem Commun (Camb). 2013 Nov 4. PMID:24185282 doi:https://dx.doi.org/10.1039/c3cc47022a
  1. ↑ Mulder MA, Nair S, Abratt VR, Zappe H, Steyn LM. Involvement of the N- and C-terminal domains of Mycobacterium tuberculosis KatG in the protection of mutant Escherichia coli against DNA-damaging agents. Microbiology. 1999 Aug;145 ( Pt 8):2011-21. PMID:10463167

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