4mnv: Difference between revisions

Line 1:

~~'''Unreleased~~ structure~~'''~~

===Crystal structure of bicyclic peptide UK729 bound as an acyl-enzyme intermediate to urokinase-type plasminogen activator (uPA)===

The ~~entry 4mnv~~ is ~~ON HOLD~~

==Disease==

[[http://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Defects in PLAU are the cause of Quebec platelet disorder (QPD) [MIM:[http://omim.org/entry/601709 601709]]. QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.<ref>PMID:20007542</ref>

~~Authors~~: ~~Chen, S~~.~~, Pojer, F~~.~~, Heinis, C~~.

==Function==

[[http://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.

~~Description~~: ~~Crystal structure of bicyclic peptide UK729 bound as an acyl~~-enzyme intermediate ~~to urokinase~~-~~type plasminogen activator (uPA)~~

==About this Structure==

[[4mnv]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MNV OCA].

==Reference==

[[Category: U-plasminogen activator]]

[[Category: Chen, S.]]

[[Category: Heinis, C.]]

[[Category: Pojer, F.]]

[[Category: Acyl-enzyme intermediate]]

[[Category: Extracellular]]

[[Category: Hydrolase-hydrolase inhibitor complex]]

[[Category: Inhibitor]]

[[Category: Protease]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4mnv|  PDB=4mnv  |  SCENE=  }}
+===Crystal structure of bicyclic peptide UK729 bound as an acyl-enzyme intermediate to urokinase-type plasminogen activator (uPA)===
+{{ABSTRACT_PUBMED_24453110}}
-The entry 4mnv is ON HOLD
+==Disease==
+[[http://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Defects in PLAU are the cause of Quebec platelet disorder (QPD) [MIM:[http://omim.org/entry/601709 601709]]. QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.<ref>PMID:20007542</ref>
-Authors: Chen, S., Pojer, F., Heinis, C.
+==Function==
+[[http://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
-Description: Crystal structure of bicyclic peptide UK729 bound as an acyl-enzyme intermediate to urokinase-type plasminogen activator (uPA)
+==About this Structure==
+[[4mnv]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MNV OCA].
+==Reference==
+<ref group="xtra">PMID:024453110</ref><references group="xtra"/><references/>
+[[Category: U-plasminogen activator]]
+[[Category: Chen, S.]]
+[[Category: Heinis, C.]]
+[[Category: Pojer, F.]]
+[[Category: Acyl-enzyme intermediate]]
+[[Category: Extracellular]]
+[[Category: Hydrolase-hydrolase inhibitor complex]]
+[[Category: Inhibitor]]
+[[Category: Protease]]