4c67: Difference between revisions

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'''Unreleased structure'''
{{STRUCTURE_4c67|  PDB=4c67  |  SCENE=  }}
===Discovery of Epigenetic Regulator I-BET762: Lead Optimization to Afford a Clinical Candidate Inhibitor of the BET Bromodomains===
{{ABSTRACT_PUBMED_24015967}}


The entry 4c67 is ON HOLD until Paper Publication
==Disease==
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>  


Authors: Chung, C., Mirguet, O.
==Function==
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).  


Description: Discovery of Epigenetic Regulator I-BET762: Lead Optimization to Afford a Clinical Candidate Inhibitor of the BET Bromodomains
==About this Structure==
[[4c67]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C67 OCA].
 
==Reference==
<ref group="xtra">PMID:024015967</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Chung, C.]]
[[Category: Mirguet, O.]]
[[Category: Antagonist]]
[[Category: Bromodomain containing protein 4]]
[[Category: Cell cycle]]
[[Category: Epigenetic reader brd4]]
[[Category: Histone]]
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