4mqs: Difference between revisions

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'''Unreleased structure'''
{{STRUCTURE_4mqs|  PDB=4mqs  |  SCENE=  }}
===Structure of active human M2 muscarinic acetylcholine receptor bound to the agonist iperoxo===


The entry 4mqs is ON HOLD
==Disease==
[[http://www.uniprot.org/uniprot/ACM2_HUMAN ACM2_HUMAN]] Disease susceptibility is associated with variations affecting the gene represented in this entry.


Authors: Kruse, A.C., Ring, A.M., Manglik, A., Hu, J., Hu, K., Eitel, K., Huebner, H., Pardon, E., Valant, C., Sexton, P.M., Christopoulos, A., Felder, C.C., Gmeiner, P., Steyaert, J., Weis, W.I., Garcia, K.C., Wess, J., Kobilka, B.K.
==Function==
[[http://www.uniprot.org/uniprot/ACM2_HUMAN ACM2_HUMAN]] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition.  


Description: Structure of active human M2 muscarinic acetylcholine receptor bound to the agonist iperoxo
==About this Structure==
[[4mqs]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MQS OCA].
[[Category: Christopoulos, A.]]
[[Category: Eitel, K.]]
[[Category: Felder, C C.]]
[[Category: Garcia, K C.]]
[[Category: Gmeiner, P.]]
[[Category: Hu, J.]]
[[Category: Hu, K.]]
[[Category: Huebner, H.]]
[[Category: Kobilka, B K.]]
[[Category: Kruse, A C.]]
[[Category: Manglik, A.]]
[[Category: Pardon, E.]]
[[Category: Ring, A M.]]
[[Category: Sexton, P M.]]
[[Category: Steyaert, J.]]
[[Category: Valant, C.]]
[[Category: Weis, W I.]]
[[Category: Wess, J.]]
[[Category: G protein-coupled receptor]]
[[Category: Muscarinic acetylcholine receptor]]
[[Category: Signaling protein]]

Revision as of 10:35, 27 November 2013

Template:STRUCTURE 4mqs

Structure of active human M2 muscarinic acetylcholine receptor bound to the agonist iperoxo

Disease

[ACM2_HUMAN] Disease susceptibility is associated with variations affecting the gene represented in this entry.

Function

[ACM2_HUMAN] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition.

About this Structure

4mqs is a 2 chain structure. Full crystallographic information is available from OCA.

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OCA

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