2off: Difference between revisions

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[[Image:2off.jpg|left|200px]]<br /><applet load="2off" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2off.jpg|left|200px]]
caption="2off, resolution 2.20&Aring;" />
 
'''The crystal structure of Glycogen Phosphorylase b in complex with a potent allosteric inhibitor'''<br />
{{Structure
|PDB= 2off |SIZE=350|CAPTION= <scene name='initialview01'>2off</scene>, resolution 2.20&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=OFF:2-DEOXY-3,4-BIS-O-[3-(4-HYDROXYPHENYL)PROPANOYL]-L-THREO-PENTARIC ACID'>OFF</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Phosphorylase Phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.1 2.4.1.1]
|GENE=
}}
 
'''The crystal structure of Glycogen Phosphorylase b in complex with a potent allosteric inhibitor'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2OFF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus] with <scene name='pdbligand=OFF:'>OFF</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Phosphorylase Phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.1 2.4.1.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OFF OCA].  
2OFF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OFF OCA].  


==Reference==
==Reference==
FR258900, a potential anti-hyperglycemic drug, binds at the allosteric site of glycogen phosphorylase., Tiraidis C, Alexacou KM, Zographos SE, Leonidas DD, Gimisis T, Oikonomakos NG, Protein Sci. 2007 Aug;16(8):1773-82. Epub 2007 Jun 28. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17600143 17600143]
FR258900, a potential anti-hyperglycemic drug, binds at the allosteric site of glycogen phosphorylase., Tiraidis C, Alexacou KM, Zographos SE, Leonidas DD, Gimisis T, Oikonomakos NG, Protein Sci. 2007 Aug;16(8):1773-82. Epub 2007 Jun 28. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17600143 17600143]
[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
[[Category: Phosphorylase]]
[[Category: Phosphorylase]]
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[[Category: type 2 diabetes]]
[[Category: type 2 diabetes]]


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:17:56 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:59:00 2008''
Retrieved from "https://proteopedia.org/2off"