2ojf: Difference between revisions

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[[Image:2ojf.gif|left|200px]]<br /><applet load="2ojf" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2ojf.gif|left|200px]]
caption="2ojf, resolution 2.10&Aring;" />
 
'''Crystal structure of Protein Kinase A in complex with Pyridine-Pyrazolopyridine based inhibitors'''<br />
{{Structure
|PDB= 2ojf |SIZE=350|CAPTION= <scene name='initialview01'>2ojf</scene>, resolution 2.10&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=4PY:(2S)-1-(6H-INDOL-3-YL)-3-{[5-(7H-PYRAZOLO[3,4-C]PYRIDIN-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE'>4PY</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/cAMP-dependent_protein_kinase cAMP-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.11 2.7.11.11]
|GENE= PRKACA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 Bos taurus])
}}
 
'''Crystal structure of Protein Kinase A in complex with Pyridine-Pyrazolopyridine based inhibitors'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2OJF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with <scene name='pdbligand=4PY:'>4PY</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/cAMP-dependent_protein_kinase cAMP-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.11 2.7.11.11] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OJF OCA].  
2OJF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OJF OCA].  


==Reference==
==Reference==
Design and synthesis of pyridine-pyrazolopyridine-based inhibitors of protein kinase B/Akt., Zhu GD, Gong J, Gandhi VB, Woods K, Luo Y, Liu X, Guan R, Klinghofer V, Johnson EF, Stoll VS, Mamo M, Li Q, Rosenberg SH, Giranda VL, Bioorg Med Chem. 2007 Mar 15;15(6):2441-52. Epub 2007 Jan 17. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17258463 17258463]
Design and synthesis of pyridine-pyrazolopyridine-based inhibitors of protein kinase B/Akt., Zhu GD, Gong J, Gandhi VB, Woods K, Luo Y, Liu X, Guan R, Klinghofer V, Johnson EF, Stoll VS, Mamo M, Li Q, Rosenberg SH, Giranda VL, Bioorg Med Chem. 2007 Mar 15;15(6):2441-52. Epub 2007 Jan 17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17258463 17258463]
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: 4PY]]
[[Category: 4PY]]
[[Category: akt]]
[[Category: akt]]
[[Category: protein kinase a]]
[[Category: protein kinase some]]


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